High molecular weight polymer-based prodrugs
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United States of America Patent
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Mar 9, 1999
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app pub date -
Sep 29, 1995
filing date -
Oct 20, 1993
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Abstract
High molecular weight, water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active moiety; M is X or Q; X is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or sulfur; R is a polyalkylene oxide; and Z is OH, C.sub.1-4 all moieties or ##STR2## are disclosed. In preferred embodiments, the prodrugs contain a polyethylene glycol having a molecular weight of at least about 20,000.
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