Modulators of the interaction between ICAM-R and .alpha..sub.d /CD18
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United States of America Patent
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Mar 9, 1999
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N/A
app pub date -
Jun 7, 1995
filing date -
Jan 27, 1992
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Abstract
DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R. Specifically, antibody substances which modulate the interaction between ICAM-R and ad/CD18 are provided.
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