Cancer drug screen based on cell cycle uncoupling

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United States of America Patent

PATENT NO 5882865
SERIAL NO

08781201

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Abstract

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Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITYBALTIMORE MD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinzler, Kenneth W BelAir, MD 296 5437
Lengauer, Christoph Columbia, MD 14 64
Vogelstein, Bert Baltimore, MD 338 7135
Waldman, Todd Bethesda, MD 12 19

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