Compositions and methods for preventing and treating allograft rejection
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United States of America Patent
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Mar 16, 1999
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N/A
app pub date -
Nov 23, 1994
filing date -
Aug 14, 1990
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Abstract
Compositions and methods are provided for the prevention and treatment of allograft rejection. Compositions are provided which comprise an antisense oligonucleotide targeted to a nucleic acid sequence encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, or endothelial leukocyte adhesion molecule-1 in combination with an immunosuppressive agent. Methods of preventing or treating allograft rejection by treating an allograft recipient with such a composition are provided. Methods for preventing allograft rejection comprising perfusion of the graft are also provided.
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