Non-invasive measurement of blood PH
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United States of America Patent
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Mar 23, 1999
Grant Date -
N/A
app pub date -
Jun 9, 1997
filing date -
Jun 13, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods and apparatus are provided for non-invasively determining blood pH by a multivariate analysis technique, such as classical least squares (CLS), partial least squares (PLS), or principal components regression (PCR). The technique employs at least one spectral factor based on the difference in the spectrum of a hemoglobin fraction (e.g., oxyhemoglobin) at two different pH's (e.g., pH 7.2 and pH 7.8). The spectral factor is preferably evaluated over the wavelength range of 520-680 nm.
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