Antibodies that react with variant CD44 surface proteins
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United States of America Patent
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Mar 23, 1999
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
May 7, 1990
priority date (Note) -
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Abstract
The inventon relates to antibodies that react with a variant epilope in the extracellular region of a variant CD44 polypeptide, wherein the variant epitope has the amino acid sequence: I S S T I S T T P R A P D H T K Q N Q D W T Q W N P S H S N P E V L L Q T T T R M T D V D R N G T T A Y E G N W N P E A H P P L I H H E H H E E E E T P H S T S T I O A T P S S T T E E T A T Q K E Q W F G N R W H E G Y R Q T P R E D S H S T T G T A A A S A H T S H P M Q G R T T P S P E D S S W T D F F N P I S H P M G R G H Q A G R R (residues 53-219 of SEQ ID NO:4). Methods of using the antibodies to identify variant epitopes also are provided.
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