Biocompatible articles and method for making same
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United States of America Patent
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Mar 23, 1999
Grant Date -
N/A
app pub date -
May 23, 1997
filing date -
May 23, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Articles of manufacture and methods of making the same, comprising a cationic polymer which has been surface-modified by a method comprising the steps of swelling a cationic polymer in a medium having a pH value <7; applying a surface-modifying agent to the cationic polymer to form a mixture; and adjusting the pH of the mixture to a value .gtoreq.7. A preferred embodiment relates to semipermeable membranes suitable for hemodialysis made from chitosan, the surface of which has been modified by anionic polysaccharides such as dextran or heparin, or anionic polyoxyalkylenes such as acid-modified polyethylene glycol, to improve blood compatibility.
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