Adenovirus with modified binding moiety specific for the target cells
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United States of America Patent
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Mar 23, 1999
Grant Date -
N/A
app pub date -
Jul 5, 1995
filing date -
Nov 4, 1992
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Expired
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Abstract
An adenovirus or adenovirus-like particle which has a modified binding specificity conferred by a binding moiety. The binding moiety is heterologous to the adenovirus and is incorporated as a fusion protein with the fiber protein. This allows the adenovirus or adenovirus-like particle to bind to a target cell which is not the natural host cell of the virus. The penton fiber is modified by the insertion or, deletion, or substitution of amino acid residues, that disrupt the host-cell binding function so that the adenovirus or adenovirous like particle does not bind the natural host cell.
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