Rapid detection and identification of nucleic acid variants
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United States of America Patent
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Mar 30, 1999
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app pub date -
Feb 19, 1997
filing date -
Dec 7, 1992
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Abstract
The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to screen for known and unknown mutations, including single base changes, in nucleic acids. Methods are provided which allow for the identification of genetic mutations and the identification bacterial and viral strains and species in a sample.
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