Method and composition for the treatment of apathy-amotivation syndrome
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United States of America Patent
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Mar 30, 1999
Issued Date -
N/A
app pub date -
Jun 29, 1995
filing date -
Feb 14, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In accordance with the present invention, neuropsychiatric symptoms of apathy-amotivation syndrome and particularly those symptoms in: Alzheimer's disease, multiple sclerosis, Huntington's chorea, frontal lobe lesions, and AIDS dementia can be ameliorated by treating a patient with a histamine H.sub.2 -antagonist that passes the blood-brain barrier. Suitable H.sub.2 -antagonists include famotidine and ranitidine. The H.sub.2 -antagonists may be co-administered with other compounds which are known to be useful in the treatment of the above neuropsychiatric conditions, and in one aspect of the invention can be formulated with such other compounds into a therapeutic composition.
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