Protein or polypeptide, method for producing the same and intermediate compound therefor
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United States of America Patent
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Mar 30, 1999
Grant Date -
N/A
app pub date -
Mar 14, 1997
filing date -
May 20, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a protein or polypeptide substance having at least one amino group bonded to a polyethyleneglycolosy group represented by the following general formula; R.sub.1 --(OCH.sub.2 CH.sub.2).sub.n --O-- (wherein R.sub.1 represents an optionally substituted cholesteryl group; and n represents a positive integer which is arbitrarily variable), and a method for producing said the protein or polypeptide. The present invention also provides a reactive polyethyleneglycol derivative as an intermediated for above the method. The chemically modified protein or polypeptide of the present invention never impairs bonding with a receptor and has a high plysiological activity. Then, a behaviors in vivo of these substance is improved. Now medical substances or drugs having a high pharmacological activity can be developed by using these substance.
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