Methodology for eliciting an analgesic response in a living subject
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United States of America Patent
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Apr 6, 1999
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N/A
app pub date -
Apr 12, 1996
filing date -
Apr 9, 1993
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Abstract
The present invention provides a method for eliciting an opioidal analgesia in a living subject using two classes of chemical compositions previously thought to have directly contradictory and physiologically antagonistic roles in the spinal analgesic process. The present methodology relies upon a concurrent administration of an opioid in marginal concentrations in combination with marginal doses of substance P or its related entities which function in a synergistic relationship and mechanism of action. The methodology relies upon a powerful potentiation and enhancement of an opioid-mediated response by the enhancing action of substance P to modulate or eliminate pain and other nociceptive responses, as well as inducing anesthesia.
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