Amyloid precursor-like protein and uses thereof
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United States of America Patent
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Apr 6, 1999
Issued Date -
N/A
app pub date -
Aug 6, 1996
filing date -
Apr 20, 1992
priority date (Note) -
Expired
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Abstract
The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic. DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.
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