Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
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United States of America Patent
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Apr 27, 1999
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N/A
app pub date -
Apr 12, 1994
filing date -
Apr 12, 1994
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Abstract
Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
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