Drug incorporating and releasing polymeric coating for bioprosthesis
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United States of America Patent
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May 4, 1999
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Mar 18, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In accordance with the present invention, there are provided prosthetic articles having polyurethane coatings with biologically active compounds incorporated within the interstices of the polymer. Methods for the preparation of such articles are also provided. Thus, a polyurethane coating is applied to a prosthetic article, the coating then swelled (without significantly dissolving the polymer) so that substantial quantities of biologically active compounds can be incorporated within the interstices of the polymer. Upon long term exposure of a prosthetic article of the invention to physiological conditions, the biologically active compound is slowly released by the treated polymer. The biologically active compound is, therefore, released only at the site where it is desired, i.e., where the prosthetic article is positioned.
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