Selective acylation method
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United States of America Patent
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May 18, 1999
Grant Date -
N/A
app pub date -
Jul 8, 1997
filing date -
Jul 11, 1996
priority date (Note) -
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Abstract
A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free .epsilon.-amino group of a Lys residue contained therein and at least one free .alpha.-amino group which method comprises reacting the .epsilon.-amino group with an activated amide in a polar solvent in the presence of a base.
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