Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
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United States of America Patent
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Jun 1, 1999
Grant Date -
N/A
app pub date -
Feb 6, 1998
filing date -
Feb 11, 1997
priority date (Note) -
Expired
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Abstract
A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of: a) reacting 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of a polyalkylene(glycol); and b) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof.
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