Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
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United States of America Patent
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Jun 8, 1999
Grant Date -
N/A
app pub date -
Oct 31, 1996
filing date -
Nov 1, 1995
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Abstract
Administrable factors or compositions to be directed to specific sites in the body of human and animal patients which comprise a medically and/or diagnostically effective moiety (I) and, coupled thereto by means of a linker (L), a substance (II) having specific affinity for specific sites in the organism. Linker 'L' has a structure schematized by the formula: Y(W-Z-R).sub.m, m being 1, 2, or 4 wherein the portion YW is an amphiphile, i.e. a segment comprised of a hydrophobic-lipophilic sequence 'Y' and a hydrophilic-lipophobic sequence 'W' connected covalently together, Z is a chemical bond or an intermediate connector sequence and R is a reactive function for effecting coupling with selected substances (II).
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