US Patent No: 5,910,301

Number of patents in Portfolio can not be more than 2000

Method of intrapulmonary administration of a narcotic drug

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ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

An aerosol formulation of an aerosol propellant and a base form of a narcotic drug selected from the group consisting of fentanyl, sufentanil and remfentanyl is provided. Such a formulation allows for the drug to be dissolved within the propellant and used within a device which does not require the use of a lubricant. Formulations are also disclosed which include lubricants, wherein the lubricant and propellant are both either polar or both non-polar. Thus, the lubricant component does not act as a solvent or cosolvent, but rather acts as a lubricant for the valve used for dispersing the formulation to a patient. Typical non-polar propellants include chlorofluorocarbons, which are typically used in connection with non-polar lubricants such as saturated vegetable oils, e.g. fractionated coconut oils. Typical polar propellants include hydrofluoroalkanes, which are typically used in connection with polar lubricants such as polyethylene glycols.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA118

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephan J Cardiff, GB 1 38
Rowe, Antony M Cardiff, GB 1 38
Rubsamen, Reid Berkeley, CA 2 81

Cited Art

Patent Info (Count) # Cites Year
 
3M INNOVATIVE PROPERTIES COMPANY (2)
5,225,183 Medicinal aerosol formulations 178 1991
5,439,670 Medicinal aerosol formulations 40 1993
 
BOEHRINGER INGELHEIM INTERNATIONAL GMBH (1)
5,497,944 Atomising devices and methods 137 1992
 
GLAXO GROUP LIMITED (1)
5,674,471 Aerosol formulations containing P134a and salbutamol 70 1995
 
HENRY, RICHARD A. (1)
5,589,156 Prilocaine and hydrofluourocarbon aerosol preparations 8 1995
 
Minnesota Mining and Manufacturing Company (1)
5,653,961 Butixocort aerosol formulations in hydrofluorocarbon propellant 47 1995
 
Riker Laboratories, Inc. (1)
4,814,161 Drug-containing chlorofluorocarbon aerosol propellent formulations 100 1986
 
THE GENERAL HOSPITAL CORPORATION (1)
5,485,827 Methods and devices for treating plumonary vasoconstriction and asthma 81 1995
 
WALES COLLEGE OF CARDIFF (1)
5,230,884 Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations 106 1992

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (20)
7,766,013 Aerosol generating method and device 3 2001
7,942,147 Aerosol forming device for use in inhalation therapy 0 2002
7,537,009 Method of forming an aerosol for inhalation delivery 6 2002
7,458,374 Method and apparatus for vaporizing a compound 13 2002
6,776,978 Delivery of opioids through an inhalation route 48 2002
7,913,688 Inhalation device for producing a drug aerosol 1 2003
7,645,442 Rapid-heating drug delivery article and method of use 3 2003
7,585,493 Thin-film drug delivery article and method of use 3 2003
7,090,830 Drug condensation aerosols and kits 50 2003
7,078,018 Delivery of opioids through an inhalation route 44 2003
7,169,378 Delivery of opioids through an inhalation route 45 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 7 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 5 2004
7,468,179 Delivery of opioids through an inhalation route 11 2007
7,981,401 Diuretic aerosols and methods of making and using them 0 2007
8,235,037 Drug condensation aerosols and kits 0 2008
7,987,846 Method and apparatus for vaporizing a compound 0 2008
8,074,644 Method of forming an aerosol for inhalation delivery 0 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 0 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 0 2009
 
ORIEL THERAPEUTICS, INC. (8)
6,889,690 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 27 2003
7,677,411 Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders 0 2003
7,118,010 Apparatus, systems and related methods for dispensing and /or evaluating dry powders 11 2003
6,985,798 Dry powder dose filling systems and related methods 8 2003
7,451,761 Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 7 2004
7,377,277 Blister packages with frames and associated methods of fabricating dry powder drug containment systems 2 2004
7,520,278 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 6 2005
7,428,446 Dry powder dose filling systems and related methods 2 2005
 
YM BIOSCIENCES INC. (2)
7,648,981 Opioid delivery system 0 2004
7,648,982 Opioid delivery system 0 2004
 
ARCHIMEDES DEVELOPMENT LIMITED (1)
8,216,604 Method of managing or treating pain 0 2008
 
DURECT CORPORATION (1)
7,074,803 Opioid formulations 3 2001
 
NOVADEL PHARMA INC. (1)
8,236,285 Buccal, polar and non-polar spray containing zolpidem 0 2009
 
NOVARTIS AG (1)
7,905,230 Metered dose inhaler with lockout 1 2003
 
NYCOMED DANMARK APS (1)
8,017,627 Fentanyl composition for nasal administration 0 2001
 
PHARMASCIENCE INC. (1)
6,455,028 Ipratropium formulation for pulmonary inhalation 5 2001
 
TAKEDA PHARMA A/S (1)
8,158,651 Fentanyl composition for nasal administration 0 2007
 
VYTERIS, INC. (1)
6,858,018 Iontophoretic devices 7 1998