Pretargeting protocols for enhanced localization of active agents to target sites
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United States of America Patent
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Jun 15, 1999
Issued Date -
N/A
app pub date -
Oct 26, 1994
filing date -
Jun 9, 1992
priority date (Note) -
Expired
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Abstract
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
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