Interferon-gamma (IFN-.gamma.) inducing factor (IGIF, IL-18) purified from murine liver
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United States of America Patent
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Jun 15, 1999
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app pub date -
Jul 14, 1995
filing date -
Jul 14, 1994
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Abstract
A protein which induces IFN-.gamma. production by immunocompetent cells and has a molecular weight of 19,000.+-.5,000 daltons on SDS-PAGE or gel filtration and a pI of 4.8.+-.1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
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