Stable budesonide solutions, method of preparing them and use of these solutions as enema preparations and pharmaceutical foams
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United States of America Patent
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Jun 22, 1999
Grant Date -
N/A
app pub date -
Jun 27, 1997
filing date -
Dec 27, 1994
priority date (Note) -
In Force
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Importance
Abstract
A stable budesonide solution with a pH not exceeding 6.0 in which the budesonide is dissolved in a solvent which may be water, an alcohol such as ethanol, isopropanol or propylene glycol, or a water/alcohol mixture. The solution preferably also contains a stabilizer such as sodium ethylenediaminetetraacetic acid, cyclodextrins or mixtures thereof. The stable budesonide solution is useful as the active ingredient in a rectal enema or a rectal foam.
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