Process for the pulsatile delivery of diltiazem HCL and product produced thereby
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United States of America Patent
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Jun 22, 1999
Grant Date -
N/A
app pub date -
Jan 27, 1997
filing date -
Jan 27, 1997
priority date (Note) -
Expired
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Abstract
A drug delivery system for diltiazem-HCl comprises: a blend of fast, medium and slow release fractions of a multi-layered diltiazem bead substrate, the fast release fraction comprised of a diltiazem bead substrate layered with a polymeric membrane coating having a membrane coating weight gain of from 14 to 18 percent, the medium release fraction comprised of a diltiazem bead substrate layered with a polymeric membrane coating having a membrane coating weight gain of from 39 to 43 percent, and the slow release fraction comprised of diltiazem bead substrate layered with polymeric membrane coating having a membrane coating weight gain of from 63 to 67 percent, wherein at least one of the polymeric membrane coatings comprises a water-insoluble, slightly permeable polymer and a plasticizer triethyl citrate.
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