Recombinant production of murine interferon--.gamma. (IFN-.gamma.) inducing factor (IGIF, IL-18)
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United States of America Patent
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Jun 22, 1999
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app pub date -
Aug 11, 1997
filing date -
Jul 14, 1994
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Abstract
DNA encoding a murine protein capable of inducing the production of interferon-.gamma. by immunocompetent cells is described. The native protein from mouse liver has a molecular weight of 19.+-.5 kDa, a pI of 4.8.+-.1.0, and the amino acid sequence shown in SEQ ID NO: 2. Methods for producing the protein in recombinant expression systems including E. coli are provided.
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