Multifunctional linking reagents for synthesis of branched oligomers

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United States of America Patent

PATENT NO 5916750
SERIAL NO

08780725

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Abstract

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Reagents capable of forming branched oligomers with monomeric units are disclosed, together with oligomers incorporating such reagents, kits containing such reagents and methods for use of such reagents in forming oligomers with monomeric units. The present reagents can advantageously be used to introduce multiple labels or reporter molecules onto oligomers such as oligonucleotides and oligopeptides. In particular, non-nucleosidic phosphoramidites based on 1,3,5-tris(2-hydroxyethyl)cyanuric acid are disclosed. Multiply-labeled, branched DNA oligomer probes constructed using these phosphoramidite reagents showed increased signal intensity relative to singly-labeled oligomer probes.

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  • BIOGENEX LABORATORIES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Inamdar, Anita Sunnyvale, CA 3 60
Iyer, Rajkumar Siva Dublin, CA 2 49
Kalra, Krishan L Danville, CA 23 1577
Su, Sheng-Hui San Ramon, CA 9 484

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