2-fluoro-9-trimethylsilyladenine
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United States of America Patent
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Jun 29, 1999
Issued Date -
N/A
app pub date -
May 20, 1993
filing date -
Jul 8, 1992
priority date (Note) -
Expired
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Abstract
A process for the preparation of 2-fluoro-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine (I) is described. The process involves reacting a protected 2-fluoro adenine with a protected chlorosugar under controlled conditions of temperature (80-85.degree. C.) to produce (I), rather than using a process involving fluorinating a 2-substituted nucleoside precursor of (I).
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