Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
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United States of America Patent
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Jul 6, 1999
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app pub date -
May 27, 1997
filing date -
Oct 2, 1992
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Abstract
The present invention relates to a novel composition comprising coagulation Factor VIII and a non-ionic surfactant such as block co-polymers, e.g. polyoxamers or polyoxyethylene (20) fatty acid esters e.g. polysorbate 20 or polysorbate 80 as a stabilizer. The composition can also comprise sodium chloride, calcium chloride, L-histidine and/or sugars or sugar alcohols.
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