Hydroxamate inhibitors of interleukin-1.beta. converting enzyme

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5919790
SERIAL NO

08942605

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ABBOTT GMBH & CO. KGWIESBADEN23
WARNER-LAMBERT COMPANY LLCMORRIS PLAINS, NJ226

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allen, Hamish John Shrewsbury, MA 7 66
Brady, Kenneth Dale Worcester, MA 7 70
Caprathe, Bradley William Livonia, MI 4 39
Galatsis, Paul Ann Arbor, MI 5 31
Gilmore, John Lodge Ann Arbor, MI 2 30
Hays, Sheryl Jeanne Ann Arbor, MI 6 42
Talanian, Robert Vincent Harvard, MA 4 57
Walker, Nigel Dossenheim, DE 11 151
Warmus, Joseph Scott Ann Arbor, MI 8 147

Cited Art Landscape

Patent Info (Count) # Cites Year
 
VERTEX PHARMACEUTICALS INCORPORATED (1)
* 5656627 Inhibitors of interleukin-1.beta. converting enzyme 67 1995
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
WELLS FARGO BUSINESS CREDIT, INC., A DELAWARE CORPORATION (2)
* 2007/0059,283 Feline IL-18 nucleic acid molecules 0 2006
* 2009/0198,043 FELINE IL-18 PROTEINS 0 2008
 
BRANDEIS UNIVERSITY (1)
9116157 Ice-cleaved alpha-synuclein as a biomarker 0 2011
 
VERTEX PHARMACEUTICALS INCORPORATED (5)
7381827 Processes and intermediates 16 2005
* 2006/0020,016 Processes and intermediates 1 2005
7834200 Processes and intermediates 1 2008
* 2009/0048,429 Processes and intermediates 0 2008
8293929 Processes and intermediates 1 2010
 
CHILDREN'S MEDICAL CENTER CORPORATION (3)
* 6673828 Analogs of 2-Phthalimidinoglutaric acid 49 1999
7112602 Methods of treating undesired angiogenesis with 2-methyl-EM-138 15 2003
* 2004/0127,545 Analogs of 2-phthalimidinoglutaric acid 5 2003
 
SMITHKLINE BEECHAM CORPORATION (1)
6420424 CCR-3 receptor antagonists 2 2000
 
Heska Corporation (4)
6818444 Canine and feline proteins, nucleic acid molecules and uses thereof 0 2001
7205143 Feline IL-12 single chain nucleic acid molecules 0 2004
7556963 Feline IL-18 nucleic acid molecules 0 2006
7928197 Feline IL-18 proteins 0 2008
 
IDUN PHARMACEUTICALS, INC. (5)
6242422 (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases 40 1998
6525024 Inhibitors of the ICE/ced-3 family of cysteine proteases 3 2001
7157430 (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases 0 2001
6969703 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2002
* 2003/0199,454 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2002
 
ASTRAZENECA AB (23)
* 2005/0026,990 Novel metalloproteinase ihibitors 0 2002
7354940 2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12 11 2003
* 2004/0138,276 Metalloproteinase inhibitors 0 2003
* 2004/0106,659 Metalloproteinase inhibitors 15 2004
* 2004/0116,486 Metalloproteinase inhibitors 16 2004
* 2004/0127,528 Metalloproteinase inhibitors 5 2004
* 2005/0256,176 Sulphonamide derivatives and their use as tace inhibitors 15 2005
7648992 Hydantoin derivatives for the treatment of obstructive airway diseases 3 2005
7700604 Hydantoin derivatives as metalloproteinase inhibitors 3 2005
7655664 Hydantoin derivatives as metalloproteinase inhibitors 3 2005
* 2008/0293,743 Novel Hydantoin Derivatives as Metalloproteinase Inhibitors 11 2005
* 2008/0032,997 Novel Hydantoin Derivatives as Metalloproteinase Inhibitors 11 2005
8183251 Hydantoin compounds and pharmaceutical compositions thereof 0 2007
* 2008/0221,139 Novel Compounds 11 2007
7666892 Metalloproteinase inhibitors 6 2008
* 2008/0262,045 Metalloproteinase Inhibitors 11 2008
7754750 Metalloproteinase inhibitors 3 2008
* 2008/0306,065 Metalloproteinase Inhibitors 11 2008
7989620 Hydantoin derivatives for the treatment of obstructive airway diseases 0 2009
* 2010/0144,771 Novel Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases 3 2009
8153673 Metalloproteinase inhibitors 0 2010
* 2010/0273,849 Metalloproteinase Inhibitors 2 2010
* 2011/0003,853 Metalloproteinase Inhibitors 2 2010
* Cited By Examiner