Articular cartilage heterografts
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United States of America Patent
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Jul 13, 1999
Issued Date -
N/A
app pub date -
Dec 18, 1997
filing date -
Sep 15, 1995
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Abstract
The invention provides an article of manufacture comprising a substantially non-immunogenic articular cartilage heterograft for implantation into humans. The invention further provides a method for preparing an articular cartilage heterograft by removing at least a portion of an articular cartilage from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic articular cartilage.
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