US Patent No: 5,922,304
Number of patents in Portfolio can not be more than 2000
Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
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Jul 13, 1999
Issued date -
Mar 9, 1995
filing date -
08/401,974
serial no -
In Force
status
Importance
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Abstract
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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First Claim
Related Publications
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International Classification(s)
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- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent | 213 | 1987 | |
| 5,409,688 Gaseous ultrasound contrast media | 164 | 1992 | |
| 5,558,855 Phase shift colloids as ultrasound contrast agents | 97 | 1993 | |
| 5,393,524 Methods for selecting and using gases as ultrasound contrast media | 159 | 1993 | |
| 5,529,766 Contrast agents | 88 | 1993 | |
| 5,536,490 Contrast agents | 97 | 1993 | |
| 5,595,723 Method for preparing storage stable colloids | 76 | 1993 | |
| 5,558,853 Phase shift colloids as ultrasound contrast agents | 136 | 1994 | |
| 5,562,893 Gas-filled microspheres with fluorine-containing shells | 82 | 1994 | |
| 5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging | 129 | 1994 | |
| 5,573,751 Persistent gaseous bubbles as ultrasound contrast media | 74 | 1994 | |
| 5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas | 99 | 1995 | |
| 5,558,094 Methods for using persistent gases as ultrasound contrast media | 92 | 1995 | |
| 5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid | 58 | 1995 | |
| 5,567,413 Flexible amphiphilic microbubbles for ultrasound | 90 | 1995 | |
| 5,676,928 Liposomes | 78 | 1995 | |
| 5,707,606 Phase shift colloids as ultrasound contrast agents | 52 | 1995 | |
| 5,707,607 Phase shift colloids as ultrasound contrast agents | 56 | 1995 | |
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| 5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 181 | 1990 | |
| 5,205,290 Low density microspheres and their use as contrast agents for computed tomography | 116 | 1991 | |
| 5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents | 89 | 1991 | |
| 5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 151 | 1991 | |
| 5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 89 | 1992 | |
| 5,352,435 Ionophore containing liposomes for ultrasound imaging | 116 | 1992 | |
| 5,281,408 Low density microspheres and their use as contrast agents for computed tomography | 136 | 1993 | |
| 5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents | 93 | 1993 | |
| 5,469,854 Methods of preparing gas-filled liposomes | 165 | 1993 | |
| 5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 169 | 1993 | |
| 5,456,900 Low density microspheres and their use as contrast agents for computed tomography | 65 | 1993 | |
| 5,542,935 Therapeutic delivery systems related applications | 244 | 1993 | |
| 5,585,112 Method of preparing gas and gaseous precursor-filled microspheres | 170 | 1993 | |
| 5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications | 126 | 1995 | |
| 5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications | 85 | 1995 | |
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| 4,276,885 Ultrasonic image enhancement | 270 | 1979 | |
| 4,265,251 Method of determining pressure within liquid containing vessel | 133 | 1979 | |
| 4,442,843 Microbubble precursors and methods for their production and use | 210 | 1981 | |
| 4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics | 265 | 1982 | |
| 4,657,756 Microbubble precursors and apparatus for their production and use | 232 | 1983 | |
| 4,681,119 Method of production and use of microbubble precursors | 197 | 1986 | |
| 5,141,738 Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof | 165 | 1991 | |
| 5,501,863 Contrast media synthesized from polyaldehydes | 112 | 1995 | |
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| 5,271,928 Stable microbubbles suspensions injectable into living organisms | 164 | 1991 | |
| 5,310,540 Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography | 122 | 1992 | |
| 5,413,774 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 132 | 1992 | |
| 5,380,519 Stable microbubbles suspensions injectable into living organisms | 149 | 1993 | |
| 5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography | 96 | 1993 | |
| 5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method | 150 | 1994 | |
| 5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography | 64 | 1995 | |
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| 4,192,859 Contrast media containing liposomes as carriers | 119 | 1978 | |
| 5,531,980 Stable microbubbles suspensions injectable into living organisms | 93 | 1994 | |
| 5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 74 | 1995 | |
| 5,567,414 Stable microbubbles suspensions injectable into living organisms | 92 | 1995 | |
| 5,643,553 Stable microbubbles suspensions injectable into living organisms | 94 | 1995 | |
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| 4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles | 202 | 1988 | |
| 5,315,997 Method of magnetic resonance imaging using diamagnetic contrast | 129 | 1992 | |
| 5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent | 116 | 1994 | |
| 5,536,489 Emulsions as contrast agents and method of use | 123 | 1995 | |
| 5,606,973 Liquid core microdroplets for ultrasound imaging | 63 | 1995 | |
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| 4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport | 153 | 1986 | |
| 4,987,154 Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use | 131 | 1987 | |
| 4,927,623 Dissolution of gas in a fluorocarbon liquid | 161 | 1988 | |
| 4,993,415 Magnetic resonance imaging with perfluorocarbon hydrides | 114 | 1990 | |
| 5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties | 90 | 1993 | |
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| 4,737,323 Liposome extrusion method | 185 | 1986 | |
| 4,781,871 High-concentration liposome processing method | 119 | 1986 | |
| 4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation | 270 | 1987 | |
| 5,013,556 Liposomes with enhanced circulation time | 453 | 1989 | |
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| 4,420,442 Manufacturing process for hollow microspheres | 106 | 1982 | |
| 4,421,562 Manufacturing process for hollow microspheres | 93 | 1983 | |
| 4,549,892 Process for producing hollow, bilayered silicate microspheres | 65 | 1983 | |
| 4,540,629 Hollow microspheres with organosilicon-silicate walls | 78 | 1984 | |
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| 5,605,673 Stabilized microbubble compositions for ultrasound | 95 | 1994 | |
| 5,540,909 Harmonic ultrasound imaging with microbubbles | 139 | 1994 | |
| 5,639,443 Stabilized microbubble compositions | 92 | 1995 | |
| 5,626,833 Ultrasound imaging method using microbubbles | 65 | 1995 | |
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| 4,921,706 Unilamellar lipid vesicles and method for their formation | 114 | 1984 | |
| 4,898,734 Polymer composite for controlled release or membrane formation | 185 | 1988 | |
| 4,893,624 Diffuse focus ultrasound hyperthermia system | 116 | 1988 | |
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| 5,196,183 Contrast agents for ultrasound imaging | 111 | 1991 | |
| 5,354,549 Iodinated esters | 73 | 1991 | |
| 5,569,449 Gaseous microparticles as ultrasound contrast agents | 85 | 1995 | |
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| 4,572,203 Contact agents for ultrasonic imaging | 251 | 1983 | |
| 4,718,433 Contrast agents for ultrasonic imaging | 238 | 1985 | |
| 4,774,958 Ultrasonic imaging agent and method of preparation | 227 | 1987 | |
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| 5,498,421 Composition useful for in vivo delivery of biologics and methods employing same | 209 | 1994 | |
| 5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging | 125 | 1995 | |
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| 4,310,505 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances | 120 | 1979 | |
| 4,310,506 Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species | 133 | 1980 | |
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| 4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures | 174 | 1985 | |
| 5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles | 221 | 1990 | |
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| 5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids | 174 | 1990 | |
| 5,558,092 Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously | 279 | 1995 | |
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| 5,137,928 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 142 | 1991 | |
| 5,190,982 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 112 | 1992 | |
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| 4,981,692 Therapeutic treatment by intramammary infusion | 80 | 1987 | |
| 5,008,050 Extrusion technique for producing unilamellar vesicles | 136 | 1989 | |
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| 4,569,836 Cancer treatment by intracellular hyperthermia | 89 | 1983 | |
| 4,731,239 Method for enhancing NMR imaging; and diagnostic use | 118 | 1986 | |
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| 5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes | 116 | 1991 | |
| 5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging | 75 | 1993 | |
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| 5,502,094 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use | 59 | 1995 | |
| 5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use | 70 | 1996 | |
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| 5,000,960 Protein coupling to lipid vesicles | 97 | 1989 | |
| 5,219,538 Gas and oxygen carrying lipid vesicles | 83 | 1991 | |
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| 5,213,804 Solid tumor treatment method and composition | 178 | 1991 | |
| 5,620,689 Liposomes for treatment of B-cell and T-cell disorders | 84 | 1995 | |
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| 4,426,330 Synthetic phospholipid compounds | 128 | 1981 | |
| 4,534,899 Synthetic phospholipid compounds | 164 | 1983 | |
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| 4,544,545 Liposomes containing modified cholesterol for organ targeting | 354 | 1983 | |
| 4,900,540 Lipisomes containing gas for ultrasound detection | 179 | 1983 | |
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| 5,192,549 Method of amphiphatic drug loading in liposomes by pH gradient | 92 | 1989 | |
| 5,316,771 Method of amphiphatic drug loading in liposomes by ammonium ion gradient | 96 | 1992 | |
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| 5,425,366 Ultrasonic contrast agents for color Doppler imaging | 220 | 1993 | |
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| 4,790,891 Process for the production of a cartridged explosive with entrapped bubbles | 81 | 1987 | |
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| 4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use | 105 | 1981 | |
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| 5,362,478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell | 132 | 1993 | |
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| 4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants | 85 | 1987 | |
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| 4,224,179 Process for the preparation of liposomes in aqueous solution | 234 | 1978 | |
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| 5,410,516 Ultrasonic processes and circuits for performing them | 199 | 1993 | |
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| 4,675,310 Liposome composition as gas transport agents | 85 | 1985 | |
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| 5,560,364 Suspended ultra-sound induced microbubble cavitation imaging | 147 | 1995 | |
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| 4,603,044 Hepatocyte Directed Vesicle delivery system | 119 | 1984 | |
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| 4,646,756 Ultra sound hyperthermia device | 122 | 1983 | |
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| 4,938,947 Aerosol composition for in vivo imaging | 82 | 1988 | |
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| 4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal | 113 | 1985 | |
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| 4,933,121 Process for forming liposomes | 76 | 1988 | |
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| 4,342,826 Immunoassay products and methods | 107 | 1981 | |
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| 4,315,514 Method and apparatus for selective cell destruction | 171 | 1980 | |
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| 4,830,858 Spray-drying method for preparing liposomes and products produced thereby | 131 | 1985 | |
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| 5,078,994 Microgel drug delivery system | 93 | 1990 | |
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| 4,331,654 Magnetically-localizable, biodegradable lipid microspheres | 221 | 1980 | |
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| 5,186,992 Braided product and method of making same | 72 | 1992 | |
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| 5,036,003 Antibodies to VPF | 38 | 1988 | |
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| 5,198,255 Stability improvements of oat R-T-E cereals by high intensity microwave heating | 12 | 1992 | |
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| 5,350,571 Emulsions of highly fluorinated organic compounds | 79 | 1992 | |
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| 5,171,755 Emulsions of highly fluorinated organic compounds | 113 | 1988 | |
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|||
| 5,205,287 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 182 | 1992 | |
|
|
|||
| 4,776,991 Scaled-up production of liposome-encapsulated hemoglobin | 118 | 1986 | |
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| 5,496,535 Fluorocarbon contrast media for use with MRI and radiographic imaging | 73 | 1991 | |
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|
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| 5,247,935 Magnetic resonance guided focussed ultrasound surgery | 111 | 1992 | |
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| 4,620,546 Ultrasound hyperthermia apparatus | 134 | 1985 | |
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| 5,672,585 Method and composition for treating thrombosis | 53 | 1995 | |
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| 4,428,924 Preparation for diagnostic radiology | 65 | 1980 | |
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| 4,229,360 Process for the dehydration of a colloidal dispersion of lipsomes | 186 | 1978 | |
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| 5,194,266 Amphotericin B/cholesterol sulfate composition and method | 73 | 1991 | |
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| 5,114,703 Percutaneous lymphography using particulate fluorocarbon emulsions | 135 | 1990 | |
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| 4,728,575 Contrast agents for NMR imaging | 117 | 1985 | |
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| 5,147,631 Porous inorganic ultrasound contrast agents | 185 | 1991 | |
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| 5,433,204 Method of assessing placentation | 134 | 1993 | |
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| 5,004,611 Pro-liposome compositions | 83 | 1988 | |
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| 4,533,254 Apparatus for forming emulsions | 245 | 1984 | |
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| 5,135,000 Method of measuring regional tissue blood flow | 97 | 1991 | |
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| 5,049,388 Small particle aerosol liposome and liposome-drug combinations for medical use | 163 | 1989 | |
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| 5,195,520 Ultrasonic manometry process in a fluid by means of microbubbles | 171 | 1991 | |
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| 4,863,717 Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging | 122 | 1986 | |
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| 5,470,582 Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles | 100 | 1993 | |
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| 4,877,561 Method of producing liposome | 86 | 1987 | |
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| 4,658,828 Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment | 142 | 1985 | |
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| 4,789,501 Glass microspheres | 156 | 1984 | |
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| 4,728,578 Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers | 85 | 1986 | |
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|
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| 5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging | 126 | 1994 | |
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| 4,689,986 Variable frequency gas-bubble-manipulating apparatus and method | 119 | 1985 | |
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| 4,586,512 Device for localized heating of biological tissues | 153 | 1985 | |
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| 5,019,370 Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging | 99 | 1989 | |
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| 4,615,879 Particulate NMR contrast agents for gastrointestinal application | 133 | 1983 | |
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| 5,045,304 Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same | 71 | 1988 | |
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| 4,822,534 Method of producing microspheres | 93 | 1987 | |
| 4,996,041 Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system | 102 | 1988 | |
| 5,315,998 Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same | 157 | 1992 | |