US Patent No: 5,922,304

Number of patents in Portfolio can not be more than 2000

Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents

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Importance

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Abstract

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Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CEREVAST THERAPEUTICS, INC.TUCSON, AZ10

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Unger, Evan C Tucson, AZ 162 7004

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5,567,414 Stable microbubbles suspensions injectable into living organisms 100 1995
5,643,553 Stable microbubbles suspensions injectable into living organisms 103 1995
 
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La Jolla Cancer Research Foundation (1)
5,672,585 Method and composition for treating thrombosis 56 1995
 
IMCOR PHARMACEUTICAL CO. (1)
5,496,535 Fluorocarbon contrast media for use with MRI and radiographic imaging 78 1991
 
BAYER INTELLECTUAL PROPERTY GMBH (1)
5,410,516 Ultrasonic processes and circuits for performing them 207 1993
 
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HemaGen/PFC (1)
5,350,571 Emulsions of highly fluorinated organic compounds 83 1992
 
Hoechst Aktiengesellschaft (1)
5,205,287 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 219 1992
 
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KABUSHIKI KAISHA TOSHIBA (1)
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SLF LIMITED PARTNERSHIP (3)
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BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (1)
5,560,364 Suspended ultra-sound induced microbubble cavitation imaging 152 1995
 
BRACCO SUISSE SA (7)
5,271,928 Stable microbubbles suspensions injectable into living organisms 176 1991
5,310,540 Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography 134 1992
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5,380,519 Stable microbubbles suspensions injectable into living organisms 178 1993
5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography 105 1993
5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method 162 1994
5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 73 1995
 
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HEMAGEN/PFC, 655 MONTGOMERY STREET, SUITE 1710, SAN FRANCISCO, CA. 94111, A LIMITED PARTNERSHIP OF CA. (1)
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SCHLIEF, REINHARD (1)
5,195,520 Ultrasonic manometry process in a fluid by means of microbubbles 174 1991
 
NIPPON STEEL CORPORATION (1)
5,147,631 Porous inorganic ultrasound contrast agents 208 1991
 
NANOSCAN IMAGING, LLC (1)
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5,213,804 Solid tumor treatment method and composition 208 1991
5,620,689 Liposomes for treatment of B-cell and T-cell disorders 94 1995
 
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5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids 218 1990
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Genentech, Inc. (1)
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ABRAXIS BIOSCIENCE, LLC (2)
5,498,421 Composition useful for in vivo delivery of biologics and methods employing same 255 1994
5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 139 1995
 
BIOCOMPATIBLES UK LIMITED (1)
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TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
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STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (1)
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ATTA (1)
* 4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants 89 1987
 
OLSON, CAMILLA (1)
5,433,204 Method of assessing placentation 158 1993
 
The Penn State Research Foundation (1)
5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging 140 1994
 
GE HEALTHCARE AS (18)
* 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent 232 1987
5,409,688 Gaseous ultrasound contrast media 168 1992
5,558,855 Phase shift colloids as ultrasound contrast agents 100 1993
5,393,524 Methods for selecting and using gases as ultrasound contrast media 163 1993
5,529,766 Contrast agents 97 1993
5,536,490 Contrast agents 109 1993
5,595,723 Method for preparing storage stable colloids 79 1993
5,558,853 Phase shift colloids as ultrasound contrast agents 143 1994
5,562,893 Gas-filled microspheres with fluorine-containing shells 87 1994
5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging 139 1994
5,573,751 Persistent gaseous bubbles as ultrasound contrast media 79 1994
5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas 104 1995
5,558,094 Methods for using persistent gases as ultrasound contrast media 97 1995
5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid 62 1995
5,567,413 Flexible amphiphilic microbubbles for ultrasound 97 1995
5,676,928 Liposomes 90 1995
5,707,606 Phase shift colloids as ultrasound contrast agents 55 1995
5,707,607 Phase shift colloids as ultrasound contrast agents 61 1995
 
INSIGHTEC LTD. (1)
5,247,935 Magnetic resonance guided focussed ultrasound surgery 125 1992
 
CARLTON MEDICAL PRODUCTS LIMITED (1)
* 4,646,756 Ultra sound hyperthermia device 154 1983
 
ALZA CORPORATION (1)
* 4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use 113 1981
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
* 4,938,947 Aerosol composition for in vivo imaging 85 1988
 
Linton Medical Services Limited (1)
* 4,428,924 Preparation for diagnostic radiology 68 1980
 
PQ CORPORATION (4)
* 4,420,442 Manufacturing process for hollow microspheres 111 1982
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* 4,549,892 Process for producing hollow, bilayered silicate microspheres 68 1983
* 4,540,629 Hollow microspheres with organosilicon-silicate walls 84 1984
 
DREWES, WILLIAM (1)
* 4,315,514 Method and apparatus for selective cell destruction 201 1980
 
NYCOMED IMAGING AS (3)
5,196,183 Contrast agents for ultrasound imaging 114 1991
5,354,549 Iodinated esters 77 1991
5,569,449 Gaseous microparticles as ultrasound contrast agents 92 1995
 
Thomson-CSF (1)
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NOVAVAX, INC. (2)
* 5,000,960 Protein coupling to lipid vesicles 100 1989
5,219,538 Gas and oxygen carrying lipid vesicles 88 1991
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
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IMARX THERAPEUTICS, INC. (2)
5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes 156 1991
5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging 78 1993
 
SCHERING AKTIENGESELLSCHAFT (6)
* 4,442,843 Microbubble precursors and methods for their production and use 232 1981
* 4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics 286 1982
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5,501,863 Contrast media synthesized from polyaldehydes 117 1995
 
CAVITATION-CONTROL TECHNOLOGY, INC. (2)
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5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles 272 1990
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (3)
* 4,921,706 Unilamellar lipid vesicles and method for their formation 134 1984
* 4,898,734 Polymer composite for controlled release or membrane formation 202 1988
* 4,893,624 Diffuse focus ultrasound hyperthermia system 153 1988
 
TECHNOMED MEDICAL SYSTEMS (1)
* 4,658,828 Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment 157 1985
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
* 5,019,370 Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging 102 1989
 
FEDERAL-MOGUL SYSTEMS PROTECTION GROUP, INC. (1)
5,186,992 Braided product and method of making same 80 1992
 
SURFACTANT TECHNOLOGIES, INC. (2)
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E. R. Squibb & Sons, Inc. (1)
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AMERICAN BIOSCIENCE, INC. (1)
5,362,478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell 148 1993
 
DR. F. KOHLER CHEMIE GMBH (2)
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CALFEE HALTER & GRISWOLD, LLP (1)
* 4,603,044 Hepatocyte Directed Vesicle delivery system 132 1984
 
WAYNE STATE UNIVERSITY (1)
* 5,045,304 Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same 74 1988
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
* 4,689,986 Variable frequency gas-bubble-manipulating apparatus and method 135 1985
 
Molecular Biosystems, Inc. (5)
* 4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles 216 1988
5,315,997 Method of magnetic resonance imaging using diamagnetic contrast 135 1992
5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent 137 1994
5,536,489 Emulsions as contrast agents and method of use 139 1995
5,606,973 Liquid core microdroplets for ultrasound imaging 66 1995
 
ILLINOIS INSTITUTE OF TECHNOLOGY, A NOT-FOR-PROFIT CORP. OF ILLINOIS (1)
* 4,776,991 Scaled-up production of liposome-encapsulated hemoglobin 123 1986
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
* 4,789,501 Glass microspheres 163 1984
 
PNC BANK, NATIONAL ASSOCIATION (1)
* 4,533,254 Apparatus for forming emulsions 271 1984
 
The Lubrizol Corporation (1)
* 4,728,578 Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers 88 1986
 
CHILDREN'S HOSPITAL RESEARCH FOUNDATION (1)
* 4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal 116 1985
 
GENERAL MILLS IP HOLDINGS II, LLC (1)
5,198,255 Stability improvements of oat R-T-E cereals by high intensity microwave heating 14 1992
 
NEXSTAR PHARMACEUTICALS, INC. (1)
* 4,728,575 Contrast agents for NMR imaging 121 1985
 
PFC THERAPEUTICS, LLC (5)
* 4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport 157 1986
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* 4,927,623 Dissolution of gas in a fluorocarbon liquid 166 1988
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5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties 100 1993
 
TARGESON, INC. (4)
5,605,673 Stabilized microbubble compositions for ultrasound 103 1994
5,540,909 Harmonic ultrasound imaging with microbubbles 143 1994
5,639,443 Stabilized microbubble compositions 104 1995
5,626,833 Ultrasound imaging method using microbubbles 69 1995
 
UNIVERSITY OF MASSACHUSETTS (2)
* 4,544,545 Liposomes containing modified cholesterol for organ targeting 409 1983
* 4,900,540 Lipisomes containing gas for ultrasound detection 215 1983
 
LIPSOME TECHNOLOGY, INC. (1)
5,194,266 Amphotericin B/cholesterol sulfate composition and method 77 1991
 
EASTMAN KODAK COMPANY (1)
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LANTHEUS MEDICAL IMAGING, INC. (15)
* 5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 200 1990
5,205,290 Low density microspheres and their use as contrast agents for computed tomography 120 1991
5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents 95 1991
* 5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 161 1991
5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 101 1992
5,352,435 Ionophore containing liposomes for ultrasound imaging 121 1992
5,281,408 Low density microspheres and their use as contrast agents for computed tomography 161 1993
5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents 96 1993
5,469,854 Methods of preparing gas-filled liposomes 202 1993
5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 194 1993
5,456,900 Low density microspheres and their use as contrast agents for computed tomography 69 1993
5,542,935 Therapeutic delivery systems related applications 272 1993
5,585,112 Method of preparing gas and gaseous precursor-filled microspheres 202 1993
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VANDERBILT UNIVERSITY (1)
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YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (2)
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
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7,001,589 Composite nanospheres and their conjugates with biomolecules 16 2004
 
BARNES-JEWISH HOSPITAL (1)
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BRACCO DIAGNOSTICS INC. (1)
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THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (1)
6,797,257 Paramagnetic polymerized protein microspheres and methods of preparation thereof 2 2001
 
GLAUKOS CORPORATION (1)
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NYCOMED IMAGING AS (1)
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IMARX PHARMACEUTICAL CORP. (1)
7,329,402 Methods of imaging and treatment 47 2003
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (3)
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7,462,488 Tissue mimicking elastography phantoms 9 2005
 
SCIMED LIFE SYSTEMS, INC. (1)
7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 1 2006
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (3)
* 6,193,951 Microparticles useful as ultrasonic contrast agents 27 1998
6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
8,486,444 Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system 0 2011
 
IMARX THERAPEUTICS, INC. (1)
7,078,015 Ultrasound imaging and treatment 28 2004
 
STRYKER NV OPERATIONS LIMITED (1)
8,101,197 Forming coils 0 2005
 
CEREVAST THERAPEUTICS, INC. (1)
7,452,551 Targeted compositions for diagnostic and therapeutic use 2 2000
 
LANTHEUS MEDICAL IMAGING, INC. (5)
8,084,056 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 2 2003
6,998,107 Composition comprising low density microspheres 7 2004
8,658,205 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2011
8,685,441 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2013
8,747,892 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2013
 
BOSTON SCIENTIFIC SCIMED, INC. (30)
7,588,780 Embolization 3 2002
7,462,366 Drug delivery particle 32 2002
7,131,997 Tissue treatment 25 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 14 2003
7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 7 2003
8,012,454 Embolization 2 2003
7,588,825 Embolic compositions 3 2003
7,736,671 Embolization 2 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 7 2004
7,976,823 Ferromagnetic particles and methods 0 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 1 2005
7,727,555 Particles 3 2005
7,963,287 Tissue-treatment methods 12 2005
8,007,509 Coil assemblies, components and methods 11 2005
7,501,179 Block copolymer particles 4 2005
7,947,368 Block copolymer particles 0 2006
8,152,839 Embolic coils 0 2006
7,611,542 Tissue treatment 6 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 8 2007
7,666,333 Embolization 2 2007
7,951,402 Drug delivery particle 0 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 18 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 0 2010
8,430,105 Tissue-treatment methods 0 2011
8,273,324 Embolization 0 2011
 
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MALLINCKRODT INC. (1)
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BRACCO SUISSE SA (1)
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* Cited By Examiner