US Patent No: 5,922,304

Number of patents in Portfolio can not be more than 2000

Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents

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Importance

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Abstract

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Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

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First Claim

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all claims..

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CEREVAST THERAPEUTICS, INC.TUCSON, AZ27

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Unger, Evan C Tucson, AZ 161 6528

Cited Art Landscape

Patent Info (Count) # Cites Year
 
GE HEALTHCARE AS (18)
4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent 223 1987
5,409,688 Gaseous ultrasound contrast media 168 1992
5,558,855 Phase shift colloids as ultrasound contrast agents 100 1993
5,393,524 Methods for selecting and using gases as ultrasound contrast media 163 1993
5,529,766 Contrast agents 97 1993
5,536,490 Contrast agents 107 1993
5,595,723 Method for preparing storage stable colloids 79 1993
5,558,853 Phase shift colloids as ultrasound contrast agents 143 1994
5,562,893 Gas-filled microspheres with fluorine-containing shells 87 1994
5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging 139 1994
5,573,751 Persistent gaseous bubbles as ultrasound contrast media 79 1994
5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas 104 1995
5,558,094 Methods for using persistent gases as ultrasound contrast media 97 1995
5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid 62 1995
5,567,413 Flexible amphiphilic microbubbles for ultrasound 97 1995
5,676,928 Liposomes 86 1995
5,707,606 Phase shift colloids as ultrasound contrast agents 55 1995
5,707,607 Phase shift colloids as ultrasound contrast agents 61 1995
 
LANTHEUS MEDICAL IMAGING, INC. (15)
5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 190 1990
5,205,290 Low density microspheres and their use as contrast agents for computed tomography 120 1991
5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents 94 1991
5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 161 1991
5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 99 1992
5,352,435 Ionophore containing liposomes for ultrasound imaging 121 1992
5,281,408 Low density microspheres and their use as contrast agents for computed tomography 153 1993
5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents 96 1993
5,469,854 Methods of preparing gas-filled liposomes 188 1993
5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 187 1993
5,456,900 Low density microspheres and their use as contrast agents for computed tomography 69 1993
5,542,935 Therapeutic delivery systems related applications 268 1993
5,585,112 Method of preparing gas and gaseous precursor-filled microspheres 194 1993
5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications 141 1995
5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications 91 1995
 
SCHERING AKTIENGESELLSCHAFT (8)
4,276,885 Ultrasonic image enhancement 288 1979
4,265,251 Method of determining pressure within liquid containing vessel 138 1979
4,442,843 Microbubble precursors and methods for their production and use 226 1981
4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics 276 1982
4,657,756 Microbubble precursors and apparatus for their production and use 238 1983
4,681,119 Method of production and use of microbubble precursors 202 1986
5,141,738 Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof 171 1991
5,501,863 Contrast media synthesized from polyaldehydes 117 1995
 
BRACCO SUISSE SA (7)
5,271,928 Stable microbubbles suspensions injectable into living organisms 174 1991
5,310,540 Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography 126 1992
5,413,774 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof 141 1992
5,380,519 Stable microbubbles suspensions injectable into living organisms 167 1993
5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography 105 1993
5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method 162 1994
5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 73 1995
 
BRACCO INTERNATIONAL B.V. (5)
4,192,859 Contrast media containing liposomes as carriers 123 1978
5,531,980 Stable microbubbles suspensions injectable into living organisms 102 1994
5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof 83 1995
5,567,414 Stable microbubbles suspensions injectable into living organisms 100 1995
5,643,553 Stable microbubbles suspensions injectable into living organisms 103 1995
 
Molecular Biosystems, Inc. (5)
4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles 208 1988
5,315,997 Method of magnetic resonance imaging using diamagnetic contrast 135 1992
5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent 130 1994
5,536,489 Emulsions as contrast agents and method of use 134 1995
5,606,973 Liquid core microdroplets for ultrasound imaging 66 1995
 
PFC THERAPEUTICS, LLC (5)
4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport 157 1986
4,987,154 Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use 135 1987
4,927,623 Dissolution of gas in a fluorocarbon liquid 166 1988
4,993,415 Magnetic resonance imaging with perfluorocarbon hydrides 120 1990
5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties 99 1993
 
Liposome Technology, Inc. (4)
4,737,323 Liposome extrusion method 205 1986
4,781,871 High-concentration liposome processing method 124 1986
4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation 291 1987
5,013,556 Liposomes with enhanced circulation time 529 1989
 
PQ CORPORATION (4)
4,420,442 Manufacturing process for hollow microspheres 110 1982
4,421,562 Manufacturing process for hollow microspheres 98 1983
4,549,892 Process for producing hollow, bilayered silicate microspheres 68 1983
4,540,629 Hollow microspheres with organosilicon-silicate walls 83 1984
 
TARGESON, INC. (4)
5,605,673 Stabilized microbubble compositions for ultrasound 102 1994
5,540,909 Harmonic ultrasound imaging with microbubbles 143 1994
5,639,443 Stabilized microbubble compositions 96 1995
5,626,833 Ultrasound imaging method using microbubbles 69 1995
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (3)
4,921,706 Unilamellar lipid vesicles and method for their formation 128 1984
4,898,734 Polymer composite for controlled release or membrane formation 196 1988
4,893,624 Diffuse focus ultrasound hyperthermia system 140 1988
 
NYCOMED IMAGING AS (3)
5,196,183 Contrast agents for ultrasound imaging 114 1991
5,354,549 Iodinated esters 77 1991
5,569,449 Gaseous microparticles as ultrasound contrast agents 92 1995
 
SLF LIMITED PARTNERSHIP (3)
4,572,203 Contact agents for ultrasonic imaging 260 1983
4,718,433 Contrast agents for ultrasonic imaging 250 1985
4,774,958 Ultrasonic imaging agent and method of preparation 237 1987
 
ABRAXIS BIOSCIENCE, LLC (2)
5,498,421 Composition useful for in vivo delivery of biologics and methods employing same 238 1994
5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 131 1995
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (2)
4,310,505 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances 123 1979
4,310,506 Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 139 1980
 
CAVITATION-CONTROL TECHNOLOGY, INC. (2)
4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures 182 1985
5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles 248 1990
 
CEREVAST THERAPEUTICS, INC. (2)
5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids 195 1990
5,558,092 Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously 319 1995
 
DR. F. KOHLER CHEMIE GMBH (2)
5,137,928 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 162 1991
5,190,982 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 115 1992
 
ELAN PHARMACEUTICALS, INC. (2)
4,981,692 Therapeutic treatment by intramammary infusion 89 1987
5,008,050 Extrusion technique for producing unilamellar vesicles 157 1989
 
GORDON, DAVID, SKOKIE, ILLINOIS (2)
4,569,836 Cancer treatment by intracellular hyperthermia 95 1983
4,731,239 Method for enhancing NMR imaging; and diagnostic use 122 1986
 
IMARX THERAPEUTICS, INC. (2)
5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes 137 1991
5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging 78 1993
 
Minnesota Mining and Manufacturing Company (2)
5,502,094 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use 72 1995
5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use 85 1996
 
NOVAVAX, INC. (2)
5,000,960 Protein coupling to lipid vesicles 100 1989
5,219,538 Gas and oxygen carrying lipid vesicles 87 1991
 
SEQUUS PHARMACEUTICALS, INC. (2)
5,213,804 Solid tumor treatment method and composition 195 1991
5,620,689 Liposomes for treatment of B-cell and T-cell disorders 92 1995
 
SURFACTANT TECHNOLOGIES, INC. (2)
4,426,330 Synthetic phospholipid compounds 140 1981
4,534,899 Synthetic phospholipid compounds 176 1983
 
UNIVERSITY OF MASSACHUSETTS (2)
4,544,545 Liposomes containing modified cholesterol for organ targeting 386 1983
4,900,540 Lipisomes containing gas for ultrasound detection 196 1983
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (2)
5,192,549 Method of amphiphatic drug loading in liposomes by pH gradient 116 1989
5,316,771 Method of amphiphatic drug loading in liposomes by ammonium ion gradient 122 1992
 
ACUSPHERE, INC. (1)
5,425,366 Ultrasonic contrast agents for color Doppler imaging 241 1993
 
AECI Limited (1)
4,790,891 Process for the production of a cartridged explosive with entrapped bubbles 84 1987
 
ALZA CORPORATION (1)
4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use 109 1981
 
AMERICAN BIOSCIENCE, INC. (1)
5,362,478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell 140 1993
 
ATTA (1)
4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants 89 1987
 
BATTELLE MEMORIAL INSTITUTE (1)
4,224,179 Process for the preparation of liposomes in aqueous solution 243 1978
 
BAYER INTELLECTUAL PROPERTY GMBH (1)
5,410,516 Ultrasonic processes and circuits for performing them 207 1993
 
BIOCOMPATIBLES UK LIMITED (1)
4,675,310 Liposome composition as gas transport agents 88 1985
 
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (1)
5,560,364 Suspended ultra-sound induced microbubble cavitation imaging 152 1995
 
CALFEE HALTER & GRISWOLD, LLP (1)
4,603,044 Hepatocyte Directed Vesicle delivery system 125 1984
 
CARLTON MEDICAL PRODUCTS LIMITED (1)
4,646,756 Ultra sound hyperthermia device 140 1983
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
4,938,947 Aerosol composition for in vivo imaging 85 1988
 
CHILDREN'S HOSPITAL RESEARCH FOUNDATION (1)
4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal 116 1985
 
CIBA CORNING DIAGNOSTICS CORP. (1)
4,933,121 Process for forming liposomes 85 1988
 
Collaborative Research, Inc. (1)
4,342,826 Immunoassay products and methods 110 1981
 
DREWES, WILLIAM (1)
4,315,514 Method and apparatus for selective cell destruction 190 1980
 
E. R. Squibb & Sons, Inc. (1)
4,830,858 Spray-drying method for preparing liposomes and products produced thereby 137 1985
 
EASTMAN KODAK COMPANY (1)
5,078,994 Microgel drug delivery system 98 1990
 
Eli Lilly and Company (1)
4,331,654 Magnetically-localizable, biodegradable lipid microspheres 263 1980
 
FEDERAL-MOGUL SYSTEMS PROTECTION GROUP, INC. (1)
5,186,992 Braided product and method of making same 77 1992
 
Genentech, Inc. (1)
5,036,003 Antibodies to VPF 39 1988
 
GENERAL MILLS IP HOLDINGS II, LLC (1)
5,198,255 Stability improvements of oat R-T-E cereals by high intensity microwave heating 14 1992
 
HemaGen/PFC (1)
5,350,571 Emulsions of highly fluorinated organic compounds 83 1992
 
HEMAGEN/PFC, 655 MONTGOMERY STREET, SUITE 1710, SAN FRANCISCO, CA. 94111, A LIMITED PARTNERSHIP OF CA. (1)
5,171,755 Emulsions of highly fluorinated organic compounds 117 1988
 
Hoechst Aktiengesellschaft (1)
5,205,287 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 201 1992
 
ILLINOIS INSTITUTE OF TECHNOLOGY, A NOT-FOR-PROFIT CORP. OF ILLINOIS (1)
4,776,991 Scaled-up production of liposome-encapsulated hemoglobin 122 1986
 
IMCOR PHARMACEUTICAL CO. (1)
5,496,535 Fluorocarbon contrast media for use with MRI and radiographic imaging 78 1991
 
INSIGHTEC LTD. (1)
5,247,935 Magnetic resonance guided focussed ultrasound surgery 122 1992
 
KABUSHIKI KAISHA TOSHIBA (1)
4,620,546 Ultrasound hyperthermia apparatus 156 1985
 
La Jolla Cancer Research Foundation (1)
5,672,585 Method and composition for treating thrombosis 56 1995
 
Linton Medical Services Limited (1)
4,428,924 Preparation for diagnostic radiology 68 1980
 
LIPOSOME COMPANY, INC., THE (1)
4,229,360 Process for the dehydration of a colloidal dispersion of lipsomes 191 1978
 
LIPSOME TECHNOLOGY, INC. (1)
5,194,266 Amphotericin B/cholesterol sulfate composition and method 77 1991
 
NANOSCAN IMAGING, LLC (1)
5,114,703 Percutaneous lymphography using particulate fluorocarbon emulsions 142 1990
 
NEXSTAR PHARMACEUTICALS, INC. (1)
4,728,575 Contrast agents for NMR imaging 121 1985
 
NIPPON STEEL CORPORATION (1)
5,147,631 Porous inorganic ultrasound contrast agents 202 1991
 
OLSON, CAMILLA (1)
5,433,204 Method of assessing placentation 150 1993
 
PHARES PHARMACEUTICAL RESEARCH N.V. (1)
5,004,611 Pro-liposome compositions 89 1988
 
PNC BANK, NATIONAL ASSOCIATION (1)
4,533,254 Apparatus for forming emulsions 263 1984
 
RAMOT AT TEL-AVIV UNIVERSITY LTD. (1)
5,135,000 Method of measuring regional tissue blood flow 104 1991
 
RESEARCH DEVELOPMENT FOUNDATION (1)
5,049,388 Small particle aerosol liposome and liposome-drug combinations for medical use 181 1989
 
SCHLIEF, REINHARD (1)
5,195,520 Ultrasonic manometry process in a fluid by means of microbubbles 174 1991
 
STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (1)
4,863,717 Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging 125 1986
 
Syntex (U.S.A.) Inc. (1)
5,470,582 Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles 104 1993
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
4,877,561 Method of producing liposome 91 1987
 
TECHNOMED MEDICAL SYSTEMS (1)
4,658,828 Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment 152 1985
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
4,789,501 Glass microspheres 162 1984
 
The Lubrizol Corporation (1)
4,728,578 Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers 88 1986
 
The Penn State Research Foundation (1)
5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging 137 1994
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
4,689,986 Variable frequency gas-bubble-manipulating apparatus and method 126 1985
 
Thomson-CSF (1)
4,586,512 Device for localized heating of biological tissues 179 1985
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
5,019,370 Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging 102 1989
 
VANDERBILT UNIVERSITY (1)
4,615,879 Particulate NMR contrast agents for gastrointestinal application 138 1983
 
WAYNE STATE UNIVERSITY (1)
5,045,304 Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same 74 1988
 
Other [Check patent profile for assignment information] (3)
4,822,534 Method of producing microspheres 98 1987
4,996,041 Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system 106 1988
5,315,998 Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same 167 1992

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (30)
7,588,780 Embolization 3 2002
7,462,366 Drug delivery particle 29 2002
7,131,997 Tissue treatment 23 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 14 2003
7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 7 2003
8,012,454 Embolization 2 2003
7,588,825 Embolic compositions 3 2003
7,736,671 Embolization 2 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 6 2004
7,976,823 Ferromagnetic particles and methods 0 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 1 2005
7,727,555 Particles 2 2005
7,963,287 Tissue-treatment methods 6 2005
8,007,509 Coil assemblies, components and methods 6 2005
7,501,179 Block copolymer particles 4 2005
7,947,368 Block copolymer particles 0 2006
8,152,839 Embolic coils 0 2006
7,611,542 Tissue treatment 6 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 5 2007
7,666,333 Embolization 2 2007
7,951,402 Drug delivery particle 0 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 10 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 0 2010
8,430,105 Tissue-treatment methods 0 2011
8,273,324 Embolization 0 2011
 
LANTHEUS MEDICAL IMAGING, INC. (5)
8,084,056 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 2 2003
6,998,107 Composition comprising low density microspheres 6 2004
8,658,205 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2011
8,685,441 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2013
8,747,892 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2013
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (3)
6,193,951 Microparticles useful as ultrasonic contrast agents 27 1998
6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
8,486,444 Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system 0 2011
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (3)
6,318,146 Multi-imaging modality tissue mimicking materials for imaging phantoms 19 1999
6,635,486 Multi-imaging modality tissue mimicking materials for imaging phantoms 12 2001
7,462,488 Tissue mimicking elastography phantoms 6 2005
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
6,866,838 Composite nanospheres and their conjugates with biomolecules 18 2002
7,001,589 Composite nanospheres and their conjugates with biomolecules 15 2004
 
BARNES-JEWISH HOSPITAL (1)
6,821,506 Site specific binding system, imaging compositions and methods 4 2001
 
BRACCO DIAGNOSTICS INC. (1)
8,058,632 Containers for pharmaceuticals, particularly for use in radioisotope generators 2 2009
 
BRACCO SUISSE SA (1)
6,042,809 Administrable compositions and methods for magnetic resonance imaging 15 1998
 
BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. (1)
7,083,572 Therapeutic delivery systems 13 2002
 
CEREVAST THERAPEUTICS, INC. (1)
7,452,551 Targeted compositions for diagnostic and therapeutic use 2 2000
 
GLAUKOS CORPORATION (1)
6,939,298 Device and method for monitoring aqueous flow within the eye 50 2003
 
IMARX PHARMACEUTICAL CORP. (1)
7,329,402 Methods of imaging and treatment 38 2003
 
IMARX THERAPEUTICS, INC. (1)
7,078,015 Ultrasound imaging and treatment 27 2004
 
MALLINCKRODT INC. (1)
6,148,655 Method for calibrating ultrasound devices and contrast agents and system therefor 7 1998
 
NYCOMED IMAGING AS (1)
6,136,292 Determination of non-functioning areas of the g.i. tract using MRI of manganese composition 2 1998
 
SCIMED LIFE SYSTEMS, INC. (1)
7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 1 2006
 
STRYKER NV OPERATIONS LIMITED (1)
8,101,197 Forming coils 0 2005
 
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (1)
6,797,257 Paramagnetic polymerized protein microspheres and methods of preparation thereof 2 2001