US Patent No: 5,922,304

Number of patents in Portfolio can not be more than 2000

Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents

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Importance

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Abstract

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Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CEREVAST MEDICAL, INC.REDMOND, WA9

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Unger, Evan C Tucson, AZ 153 7910

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MINNESOTA MINING AND MANUFACTURING COMPANY (2)
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5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use 95 1996
 
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BRACCO INTERNATIONAL B.V. (4)
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5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof 87 1995
5,567,414 Stable microbubbles suspensions injectable into living organisms 106 1995
5,643,553 Stable microbubbles suspensions injectable into living organisms 109 1995
 
RAMOT AT TEL-AVIV UNIVERSITY LTD. (1)
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ACUSPHERE, INC. (1)
5,425,366 Ultrasonic contrast agents for color Doppler imaging 259 1993
 
La Jolla Cancer Research Foundation (1)
5,672,585 Method and composition for treating thrombosis 58 1995
 
IMCOR PHARMACEUTICAL CO. (1)
5,496,535 Fluorocarbon contrast media for use with MRI and radiographic imaging 79 1991
 
BAYER INTELLECTUAL PROPERTY GMBH (1)
5,410,516 Ultrasonic processes and circuits for performing them 209 1993
 
SYNTEX (U.S.A.) INC. (1)
5,470,582 Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles 106 1993
 
ELI LILLY AND COMPANY (1)
* 4,331,654 Magnetically-localizable, biodegradable lipid microspheres 307 1980
 
HEMAGEN/PFC (1)
5,350,571 Emulsions of highly fluorinated organic compounds 85 1992
 
HOECHST AKTIENGESELLSCHAFT (1)
5,205,287 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 241 1992
 
Liposome Technology, Inc. (4)
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AECI LIMITED (1)
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KABUSHIKI KAISHA TOSHIBA (1)
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SLF LIMITED PARTNERSHIP (3)
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ELAN PHARMACEUTICALS, INC. (2)
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BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (1)
5,560,364 Suspended ultra-sound induced microbubble cavitation imaging 152 1995
 
BRACCO SUISSE SA (7)
5,271,928 Stable microbubbles suspensions injectable into living organisms 188 1991
5,310,540 Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography 143 1992
5,413,774 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof 153 1992
5,380,519 Stable microbubbles suspensions injectable into living organisms 197 1993
5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography 116 1993
5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method 174 1994
5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 78 1995
 
Research Development Foundation (1)
* 5,049,388 Small particle aerosol liposome and liposome-drug combinations for medical use 198 1989
 
HEMAGEN/PFC, 655 MONTGOMERY STREET, SUITE 1710, SAN FRANCISCO, CA. 94111, A LIMITED PARTNERSHIP OF CA. (1)
5,171,755 Emulsions of highly fluorinated organic compounds 119 1988
 
SCHLIEF, REINHARD (1)
5,195,520 Ultrasonic manometry process in a fluid by means of microbubbles 174 1991
 
NIPPON STEEL CORPORATION (1)
5,147,631 Porous inorganic ultrasound contrast agents 217 1991
 
NanoScan Imaging LLC (1)
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SEQUUS PHARMACEUTICALS INC., A CORPORATION OF DELAWARE (2)
5,213,804 Solid tumor treatment method and composition 228 1991
5,620,689 Liposomes for treatment of B-cell and T-cell disorders 97 1995
 
CEREVAST THERAPEUTICS, INC. (2)
5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids 254 1990
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Collaborative Research, Inc. (1)
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Genentech, Inc. (1)
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ABRAXIS BIOSCIENCE, LLC (2)
5,498,421 Composition useful for in vivo delivery of biologics and methods employing same 278 1994
5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 148 1995
 
BIOCOMPATIBLES UK LIMITED (1)
* 4,675,310 Liposome composition as gas transport agents 88 1985
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
* 4,877,561 Method of producing liposome 93 1987
 
STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (1)
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ATTA (1)
* 4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants 89 1987
 
OLSON, CAMILLA (1)
5,433,204 Method of assessing placentation 168 1993
 
The Penn State Research Foundation (1)
5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging 151 1994
 
GE HEALTHCARE AS (18)
* 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent 245 1987
5,409,688 Gaseous ultrasound contrast media 168 1992
5,558,855 Phase shift colloids as ultrasound contrast agents 102 1993
5,393,524 Methods for selecting and using gases as ultrasound contrast media 165 1993
5,529,766 Contrast agents 101 1993
5,536,490 Contrast agents 115 1993
5,595,723 Method for preparing storage stable colloids 82 1993
5,558,853 Phase shift colloids as ultrasound contrast agents 143 1994
5,562,893 Gas-filled microspheres with fluorine-containing shells 87 1994
5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging 144 1994
5,573,751 Persistent gaseous bubbles as ultrasound contrast media 79 1994
5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas 104 1995
5,558,094 Methods for using persistent gases as ultrasound contrast media 97 1995
5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid 63 1995
5,567,413 Flexible amphiphilic microbubbles for ultrasound 98 1995
5,676,928 Liposomes 93 1995
5,707,606 Phase shift colloids as ultrasound contrast agents 55 1995
5,707,607 Phase shift colloids as ultrasound contrast agents 61 1995
 
INSIGHTEC LTD. (1)
5,247,935 Magnetic resonance guided focussed ultrasound surgery 135 1992
 
Carlton Medical Products Limited (1)
* 4,646,756 Ultra sound hyperthermia device 193 1983
 
ALZA CORPORATION (1)
* 4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use 119 1981
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
* 4,938,947 Aerosol composition for in vivo imaging 85 1988
 
Linton Medical Services Limited (1)
* 4,428,924 Preparation for diagnostic radiology 68 1980
 
PQ CORPORATION (4)
* 4,420,442 Manufacturing process for hollow microspheres 113 1982
* 4,421,562 Manufacturing process for hollow microspheres 99 1983
* 4,549,892 Process for producing hollow, bilayered silicate microspheres 68 1983
* 4,540,629 Hollow microspheres with organosilicon-silicate walls 84 1984
 
DREWES, WILLIAM (1)
* 4,315,514 Method and apparatus for selective cell destruction 218 1980
 
NYCOMED IMAGING AS (3)
5,196,183 Contrast agents for ultrasound imaging 114 1991
5,354,549 Iodinated esters 77 1991
5,569,449 Gaseous microparticles as ultrasound contrast agents 93 1995
 
THOMSON-CSF (1)
* 4,586,512 Device for localized heating of biological tissues 216 1985
 
NOVAVAX, INC. (2)
* 5,000,960 Protein coupling to lipid vesicles 100 1989
5,219,538 Gas and oxygen carrying lipid vesicles 88 1991
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
* 4,310,506 Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 145 1980
 
IMARX THERAPEUTICS, INC. (2)
5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes 180 1991
5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging 78 1993
 
SCHERING AKTIENGESELLSCHAFT (6)
* 4,442,843 Microbubble precursors and methods for their production and use 239 1981
* 4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics 301 1982
* 4,657,756 Microbubble precursors and apparatus for their production and use 258 1983
* 4,681,119 Method of production and use of microbubble precursors 224 1986
* 5,141,738 Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof 181 1991
5,501,863 Contrast media synthesized from polyaldehydes 119 1995
 
CAVITATION-CONTROL TECHNOLOGY, INC. (2)
* 4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures 205 1985
5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles 313 1990
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (3)
* 4,921,706 Unilamellar lipid vesicles and method for their formation 139 1984
* 4,898,734 Polymer composite for controlled release or membrane formation 206 1988
* 4,893,624 Diffuse focus ultrasound hyperthermia system 172 1988
 
TECHNOMED MEDICAL SYSTEMS (1)
* 4,658,828 Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment 165 1985
 
University of Kentucky Research Foundation (1)
* 5,019,370 Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging 103 1989
 
FEDERAL-MOGUL SYSTEMS PROTECTION GROUP, INC. (1)
5,186,992 Braided product and method of making same 83 1992
 
SURFACTANT TECHNOLOGIES, INC. (2)
* 4,426,330 Synthetic phospholipid compounds 158 1981
* 4,534,899 Synthetic phospholipid compounds 190 1983
 
E.R. SQUIBB & SONS, INC. (1)
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AMERICAN BIOSCIENCE, INC. (1)
5,362,478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell 157 1993
 
DR. F. KOHLER CHEMIE GMBH (2)
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5,190,982 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 115 1992
 
CALFEE HALTER & GRISWOLD, LLP (1)
* 4,603,044 Hepatocyte Directed Vesicle delivery system 139 1984
 
WAYNE STATE UNIVERSITY (1)
* 5,045,304 Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same 74 1988
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
* 4,689,986 Variable frequency gas-bubble-manipulating apparatus and method 148 1985
 
Molecular Biosystems, Inc. (5)
* 4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles 226 1988
5,315,997 Method of magnetic resonance imaging using diamagnetic contrast 135 1992
5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent 143 1994
5,536,489 Emulsions as contrast agents and method of use 149 1995
5,606,973 Liquid core microdroplets for ultrasound imaging 66 1995
 
ILLINOIS INSTITUTE OF TECHNOLOGY, A NOT-FOR-PROFIT CORP. OF ILLINOIS (1)
* 4,776,991 Scaled-up production of liposome-encapsulated hemoglobin 125 1986
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
* 4,789,501 Glass microspheres 169 1984
 
PNC BANK, NATIONAL ASSOCIATION (1)
* 4,533,254 Apparatus for forming emulsions 281 1984
 
The Lubrizol Corporation (1)
* 4,728,578 Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers 91 1986
 
Childrenʼs Hospital Research Foundation (1)
* 4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal 116 1985
 
GENERAL MILLS IP HOLDINGS II, LLC (1)
5,198,255 Stability improvements of oat R-T-E cereals by high intensity microwave heating 14 1992
 
NEXSTAR PHARMACEUTICALS, INC. (1)
* 4,728,575 Contrast agents for NMR imaging 122 1985
 
PFC THERAPEUTICS, LLC (5)
* 4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport 158 1986
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* 4,927,623 Dissolution of gas in a fluorocarbon liquid 168 1988
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5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties 113 1993
 
TARGESON, INC. (4)
5,605,673 Stabilized microbubble compositions for ultrasound 109 1994
5,540,909 Harmonic ultrasound imaging with microbubbles 146 1994
5,639,443 Stabilized microbubble compositions 113 1995
5,626,833 Ultrasound imaging method using microbubbles 70 1995
 
UNIVERSITY OF MASSACHUSETTS (2)
* 4,544,545 Liposomes containing modified cholesterol for organ targeting 456 1983
* 4,900,540 Lipisomes containing gas for ultrasound detection 242 1983
 
LIPSOME TECHNOLOGY, INC. (1)
5,194,266 Amphotericin B/cholesterol sulfate composition and method 77 1991
 
EASTMAN KODAK COMPANY (1)
* 5,078,994 Microgel drug delivery system 99 1990
 
LANTHEUS MEDICAL IMAGING, INC. (15)
* 5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 216 1990
5,205,290 Low density microspheres and their use as contrast agents for computed tomography 121 1991
5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents 97 1991
* 5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 166 1991
5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 105 1992
5,352,435 Ionophore containing liposomes for ultrasound imaging 122 1992
5,281,408 Low density microspheres and their use as contrast agents for computed tomography 170 1993
5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents 96 1993
5,469,854 Methods of preparing gas-filled liposomes 227 1993
5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 205 1993
5,456,900 Low density microspheres and their use as contrast agents for computed tomography 69 1993
5,542,935 Therapeutic delivery systems related applications 289 1993
5,585,112 Method of preparing gas and gaseous precursor-filled microspheres 219 1993
5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications 150 1995
5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications 93 1995
 
GORDON, DAVID, SKOKIE, ILLINOIS (2)
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Phares Pharmaceutical Research, N.V. (1)
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VANDERBILT UNIVERSITY (1)
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YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (2)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 2003/0012,735 Methods for diagnostic imaging by regulating the administration rate of contrast agent 5 2002
* 2005/0013,780 Hollow microspheres with controlled fragility for medical use 0 2004
 
WELLS FARGO BANK, NATIONAL ASSOCIATION (2)
8,685,441 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2013
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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (3)
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7,001,589 Composite nanospheres and their conjugates with biomolecules 20 2004
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POINT BIOMEDICAL CORPORATION (3)
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BARNES-JEWISH HOSPITAL (2)
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BRACCO DIAGNOSTICS INC. (2)
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THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (1)
6,797,257 Paramagnetic polymerized protein microspheres and methods of preparation thereof 2 2001
 
GLAUKOS CORPORATION (2)
6,939,298 Device and method for monitoring aqueous flow within the eye 88 2003
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NYCOMED IMAGING AS (1)
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IMARX PHARMACEUTICAL CORP. (1)
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SUNNYBROOK AND WOMEN'S COLLEGE HEALTH SCIENCES CENTRE (1)
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WICKLINE SAMUEL A M D (1)
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WISCONSIN ALUMNI RESEARCH FOUNDATION (5)
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SCIMED LIFE SYSTEMS, INC. (2)
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7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 4 2006
 
IMARX THERAPEUTICS, INC. (3)
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UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (5)
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6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
* 2006/0013,771 Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging 0 2005
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8,486,444 Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system 0 2011
 
STRYKER EUROPEAN HOLDINGS I, LLC (1)
8,101,197 Forming coils 0 2005
 
CEREVAST MEDICAL, INC. (1)
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LANTHEUS MEDICAL IMAGING, INC. (4)
8,084,056 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 2 2003
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BOSTON SCIENTIFIC SCIMED, INC. (32)
7,588,780 Embolization 5 2002
7,462,366 Drug delivery particle 34 2002
7,131,997 Tissue treatment 33 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 17 2003
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7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 9 2003
8,012,454 Embolization 3 2003
7,588,825 Embolic compositions 5 2003
7,736,671 Embolization 5 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 10 2004
7,976,823 Ferromagnetic particles and methods 1 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 2 2005
7,727,555 Particles 5 2005
7,963,287 Tissue-treatment methods 20 2005
8,007,509 Coil assemblies, components and methods 13 2005
7,501,179 Block copolymer particles 5 2005
7,947,368 Block copolymer particles 1 2006
8,152,839 Embolic coils 2 2006
7,611,542 Tissue treatment 9 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 31 2007
7,666,333 Embolization 4 2007
7,951,402 Drug delivery particle 3 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 31 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 1 2010
8,430,105 Tissue-treatment methods 1 2011
8,273,324 Embolization 0 2011
9,283,035 Tissue-treatment methods 0 2013
 
BRISTOL-MYERS SQUIBB PHARMA COMPANY (1)
* 2003/0044,354 Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release 10 2001
 
HORIZON TECHNOLOGY FUNDING COMPANY LLC (1)
* 2004/0086,459 Microparticles useful as ultrasonic contrast agents 3 2003
 
BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. (2)
7,083,572 Therapeutic delivery systems 21 2002
* 2003/0003,055 Methods of preparing gaseous precursor-filled microspheres 3 2002
 
MALLINCKRODT INC. (1)
* 6,148,655 Method for calibrating ultrasound devices and contrast agents and system therefor 7 1998
 
BRACCO SUISSE SA (1)
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* Cited By Examiner