Composition and method of preparing microparticles of water-insoluble substances
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United States of America Patent
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Jul 13, 1999
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N/A
app pub date -
Sep 29, 1997
filing date -
Aug 22, 1996
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Abstract
Submicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage.
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