Detection as chromosomal translocations by extending and ligating differentially-labeled probes Hybridized on different sides of a break-point
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United States of America Patent
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Jul 13, 1999
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N/A
app pub date -
Mar 14, 1997
filing date -
Mar 15, 1996
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Expired
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Abstract
A composition and method of producing a composition which is directed to a single nucleic acid comprising a first section complementary to a sequence of a first chromosome, and comprising at least a first label, and a second nucleic acid section complementary to a sequence of a second chromosome, the second label being different from the first label. It is used for detecting translocations such that the single nucleic acid probe has different interactive labels on each side of a translocation break-point region.
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