Acylated Insulin Analogs
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United States of America Patent
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Jul 13, 1999
Issued Date -
N/A
app pub date -
Nov 26, 1997
filing date -
Nov 17, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to the field of diabetes. More particularly, the invention relates to a monomeric insulin analog wherein the A chain is the naturally occurring sequence of the human insulin A chain and the B chain is modified at either position B28 and B29 or both. The analog is mono-acylated at the N-terminal of the A chain or B chain or at the lysine. The acylated insulin analogs have an extended duration of action.
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