Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
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United States of America Patent
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Jul 27, 1999
Grant Date -
N/A
app pub date -
Jan 22, 1998
filing date -
Apr 25, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule having a negatively charged moiety is combined with a medical device surface having a positively charged guanidino moiety to form an ionic bond immobilizing a coating of the biomolecule on the surface. In another method, the medical device surface contains an amine moiety that is combined with a guanidino forming agent to form a positively charged guanidino moiety that is combined with the negatively charged moiety to form the ionic bond. In a further embodiment, the medical device surface contains a negatively charged moiety, and a biomolecule containing an amine moiety is combined with a guanidino forming agent to form a positively charged guanidino moiety that is combined with the negatively charged moiety to form the ionic bond.
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