Controlled release preparations for cytotoxic or cytostatic drugs
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United States of America Patent
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Aug 3, 1999
Grant Date -
N/A
app pub date -
Dec 2, 1996
filing date -
Nov 18, 1993
priority date (Note) -
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Abstract
A controlled release preparation comprises an ionic polymer matrix loaded with an active compound, particularly a pharmaceutically active compound such as doxorubicin or other cytotoxic or cytostatic drug, the active compound being complexed with a complexing agent such as a metal ion to modify the release of the active compound from the polymer matrix. The ionic polymer matrix may be provided in the form of microspheres, such as microspheres of crosslinked albumin/dextran sulphate.
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