Budesonide pellets with a controlled released pattern and process for producing the same
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United States of America Patent
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Aug 3, 1999
Grant Date -
N/A
app pub date -
Jul 15, 1996
filing date -
Sep 23, 1993
priority date (Note) -
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status (Latency Note)
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Abstract
Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.
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