Adenosine receptor agonists for the promotion of wound healing

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United States of America Patent

PATENT NO 5932558
SERIAL NO

08712942

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Agonists of the adenosine A.sub.2 receptor promote the migration of endothelial cells, fibroblasts and epithelial cells. Thus, methods and pharmaceutical compositions useful for treating wounds and promoting wound healing comprise agents which cause stimulation of the adenosine A.sub.2 receptor, preferably receptor agonists and adenosine uptake blockers. Preferred agonists include 2-phenylaminoadenosine, 2-para-2-carboxyethylphenyl-amino-5'N-ethylcarboxamidoadenosine, 5'N-ethylcarbox-amidoadenosine, 5'N-cyclopropyladenosine, 5'N-methyl-carboxamidoadenosine and PD-125944. Preferred uptake blockers include dipyridamole, nitrobenzylthio-inosine, dilazep and R75231.

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Patent Owner(s)

Patent OwnerAddress
NEW YORK UNIVERSITYNEW YORK NY 10012-1091

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cronstein, Bruce N New York, NY 15 87
Levin, Richard I New York, NY 4 582

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