Compositions and methods for modulating growth of a tissue in a mammal
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United States of America Patent
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Aug 10, 1999
Issued Date -
N/A
app pub date -
Aug 5, 1997
filing date -
Apr 23, 1989
priority date (Note) -
Expired
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Abstract
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
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