Gene encoding mutant L3T4 protein which facilitates HIV infection and transgenic mouse expressing such protein
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United States of America Patent
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Aug 10, 1999
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N/A
app pub date -
Apr 15, 1997
filing date -
Aug 16, 1991
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Expired
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Abstract
Disclosed are (1) a DNA sequence encoding a mutant L3T4 protein which, when expressed on the surface of a cell, is capable of facilitating infection of the cell by human immunodeficiency virus; the mutant protein includes at least one amino acid residue substitution or deletion in a segment corresponding to the gp120 binding epitope of a native L3T4 protein so as to increase homology between that segment and its counterpart in a CD4 protein; (2) a murine cell line or strain transfected with such a DNA sequence; and (3) a transgenic mouse susceptible to infection by human immunodeficiency virus.
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