Chemical compounds having PDE-IV inhibition activity

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United States of America Patent

PATENT NO 5939422
SERIAL NO

08578580

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed is a compound of the formula (I): wherein R.sub.3, R.sub.6a and R.sub.8 are the same or different and represent a C.sub.2-8 alkyl which is unbranched or branched and unsubstituted or substituted; C.sub.3-8 cycloalkyl which is unsubstituted or substituted; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted; aryl which is unsubstituted or substituted; aralkyl C.sub.1-4 ; heterocyclyl; and heterocyclylalkyl (C.sub.1 -C.sub.4) R.sub.6b represents H or R.sub.6a, or together R.sub.6b, N, and R.sub.6a make a C.sub.3 -C.sub.8 ring containing from one to three nitrogen atoms, from zero to two oxygen atoms, from zero to two sulfur atoms, which is optionally substituted; and where aryl is phenyl or naphthyl, the heterocyclyl is a 5, 6 or 7 membered ring including from one to three nitrogen atoms, and from zero to two oxygen atoms, from zero to two sulfur atoms, and can be substituted as in aryl on the carbons or nitrogens of that ring; or a pharmaceutically acceptable salt thereof.

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Patent Owner(s)

Patent OwnerAddress
EURO-CELTIQUE S A2350 LUXEMBOURG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cavalla, David Cambridge, GB 28 74
Chasin, Mark Manalapan, NJ 116 12920
Gehrig, Anddre Basel, CH 1 8
Hofer, Peter Liestal, CH 56 1088
Wintergest, Peter Basel, CH 1 8

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