Platelet GPIII P1.sup.A1 and P1.sup.A2 epitopes, their preparation and use
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United States of America Patent
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Aug 17, 1999
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N/A
app pub date -
Dec 9, 1991
filing date -
Dec 9, 1991
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Abstract
Polypeptides and fusion polypeptides that immunologically mimic the native Pl.sup.A1 and Pl.sup.A2 determinants of platelet protein GPIIIa are disclosed. Also disclosed are DNA segments and recombinant DNA molecules that encode those polypeptides and fusion polypeptides and methods for expressing and using those determinants. Antibodies that immunoreact with one determinant or the other, but not both are also disclosed, as are methods of preparing and using those antibodies.
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