Haemoglobin
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United States of America Patent
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Aug 24, 1999
Grant Date -
N/A
app pub date -
Jun 17, 1996
filing date -
Sep 14, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed is a mutant human .beta. globin modified so as to exhibit, when present as part of a hemoglobin molecule, an altered bicarbonate effect compared to the unmodified .beta. globin. The .beta. globin is modified to contain at positions 29-41 at least two non-wild type amino acid residues selected from the group consisting of amino acid residues 29-41 of crocodile .beta.-globin SEQ ID NO:2 to produce an enhanced bicarbonate effect.
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