Cyclic peptides that bind to urokinase-type plasminogen activator receptor
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United States of America Patent
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Aug 24, 1999
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app pub date -
Nov 12, 1996
filing date -
Nov 12, 1996
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Abstract
Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C.sup..alpha. carbon of the first amino acid and the C.sup..alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.
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