Methods and compositions for multiple gene transfer into bone cells
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United States of America Patent
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Aug 24, 1999
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N/A
app pub date -
Sep 30, 1994
filing date -
Feb 18, 1994
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Abstract
Disclosed are methods, compositions, kits and devices for use in transferring nucleic acids into bone cells in situ and/or for stimulating bone progenitor cells. Type II collagen and, particularly, osteotropic genes, are shown to stimulate bone progenitor cells and to promote bone growth, repair and regeneration in vivo. Gene transfer protocols are disclosed for use in transferring various nucleic acid materials into bone, as may be used in treating various bone-related diseases and defects including fractures, osteoporosis, osteogenesis imperfecta and in connection with bone implants.
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