US Patent No: 5,944,687

Number of patents in Portfolio can not be more than 2000

Opto-acoustic transducer for medical applications

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Abstract

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This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
LAWRENCE LIVERMORE NATIONAL SECURITY, LLCLIVERMORE, CA1425

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benett, William Livermore, CA 10 228
Celliers, Peter Berkeley, CA 6 145
Da, Silva Luiz Danville, CA 14 434
Glinsky, Michael Livermore, CA 8 234
Krulevich, Peter Pleasanton, CA 2 66
Lee, Abraham Irvine, CA 8 69
London, Richard Mellingen, CH 10 229
Maitland, Duncan Livermore, CA 6 136
Matthews, Dennis Moss Beach, CA 10 395

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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CYBERSONICS, INC. (3)
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Eli Lilly and Company (2)
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Messerschmitt-Bolkow-Blohm GmbH (2)
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Endo Technic Corporation (1)
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GENERAL ELECTRIC COMPANY (1)
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IHD, INC. (1)
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INSTITUT NATIONAL DE LA SANTE (1)
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Laser Centers of America (1)
5,342,355 Energy delivering cap element for end of optic fiber conveying laser energy 32 1992
 
LUMENIS INC. (1)
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LUMENIS, LTD. (1)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
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MEDILASE, INC. (1)
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MEDRAD, INC. (1)
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Northgate Technologies, Inc. (1)
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Rare Earth Medical Lasers, Inc. (1)
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Summit Technology, Inc. (1)
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The Beth Israel Hospital Association (1)
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The United States of America as represented by the Secretary of the Army (1)
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TYCO HEALTHCARE GROUP LP (1)
5,380,273 Vibrating catheter 100 1993
 
UNIVERSITY OF STRATHCLYDE (1)
4,844,585 Optically excited vibratile transducer 6 1988
 
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WHITE STAR HOLDINGS LTD. (1)
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YALE UNIVERSITY (1)
5,350,375 Methods for laser induced fluorescence intensity feedback control during laser angioplasty 74 1993
 
Other [Check patent profile for assignment information] (11)
4,334,321 Opto-acoustic transducer and telephone receiver 73 1981
4,503,564 Opto-acoustic transducer for a telephone receiver 59 1982
4,576,177 Catheter for removing arteriosclerotic plaque 213 1983
4,589,415 Method and system for fragmenting kidney stones 97 1984
4,887,605 Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining 108 1988
4,832,024 Cardio-vascular catheter for shooting a laser beam 148 1988
5,059,200 Laser lithotripsy 25 1990
5,152,768 Electrohydraulic lithotripsy 17 1991
5,377,683 Ultrasound-laser surgery apparatus and method 35 1991
5,324,282 Surgical instrument with input power transducer 35 1992
5,304,171 Catheter devices and methods for delivering 76 1993

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Vascular Imaging Corporation (12)
7,245,789 Systems and methods for minimally-invasive optical-acoustic imaging 31 2002
7,527,594 Optical-acoustic imaging device 8 2003
7,599,588 Optical imaging probe connector 7 2005
7,447,388 Systems and methods for minimally-invasive optical-acoustic imaging 15 2007
7,660,492 Systems and methods for minimally-invasive optical-acoustic imaging 10 2008
8,560,048 Optical ultrasound receiver 0 2009
7,881,573 Optical imaging probe connector 5 2009
8,059,923 Systems and methods for minimally-invasive optical-acoustic imaging 7 2010
8,320,723 Optical imaging probe connector 2 2011
8,391,652 Systems and methods for minimally-invasive optical-acoustic imaging 4 2011
8,861,908 Optical imaging probe 0 2012
8,731,340 Systems and methods for minimally-invasive optical-acoustic imaging 1 2013
 
PALOMAR MEDICAL TECHNOLOGIES, LLC (8)
8,346,347 Skin optical characterization device 2 2006
7,942,915 Phototreatment device for use with coolants 4 2006
7,942,916 Phototreatment device for use with coolants and topical substances 8 2006
8,328,794 System for electromagnetic radiation dermatology and head for use therewith 0 2008
7,935,107 Heads for dermatology treatment 8 2010
8,002,768 Light energy delivery head 3 2010
8,109,924 Heads for dermatology treatment 0 2011
8,328,796 Light energy delivery head 0 2011
 
CYBERSONICS, INC. (6)
7,494,468 Ultrasonic medical device operating in a transverse mode 60 2003
7,503,895 Ultrasonic device for tissue ablation and sheath for use therewith 45 2003
7,794,414 Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes 3 2004
7,775,994 Ultrasound medical systems and related methods 1 2006
8,790,359 Medical systems and related methods 0 2007
8,075,504 Ultrasound medical systems and related methods 0 2010
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (4)
6,309,352 Real time optoacoustic monitoring of changes in tissue properties 30 1998
6,405,069 Time-resolved optoacoustic method and system for noninvasive monitoring of glucose 18 1999
7,430,445 Noninvasive blood analysis by optical probing of the veins under the tongue 2 2004
8,352,005 Noninvasive blood analysis by optical probing of the veins under the tongue 0 2008
 
SELVA MEDICAL, INC. (3)
6,368,318 Opto-acoustic recanilization delivery system 3 1998
6,210,400 Flexible flow apparatus and method for the disruption of occlusions 20 1998
6,440,124 Flexible flow apparatus and method for the disruption of occlusions 4 2000
 
Endo Vasix, Inc. (2)
6,547,779 Flexible flow apparatus and method for the disruption of occlusions 46 1999
6,527,763 Flow apparatus for the disruption of occlusions 21 2001
 
THE GEORGE WASHINGTON UNIVERSITY (2)
7,999,945 Optical coherence tomography / acoustic radiation force imaging probe 2 2008
8,184,351 Amplified bimorph scanning mirror, optical system and method of scanning 0 2009
 
ALLERGAN SALES, INC. (1)
6,193,683 Closed loop temperature controlled phacoemulsification system to prevent corneal burns 54 1999
 
AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTE. LTD. (1)
7,359,523 Fluidic acoustic transducer 1 2003
 
Cardiocavitational Systems, Inc. (1)
6,755,821 System and method for stimulation and/or enhancement of myocardial angiogenesis 15 1999
 
DEPUY ACROMED, INC. (1)
7,081,113 Helical probe 5 2003
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (1)
6,379,325 Opto-acoustic transducer for medical applications 19 1999
 
PALOMAR MEDICAL TECHNOLOGIES, INC. (1)
8,182,473 Cooling system for a photocosmetic device 4 2006
 
TU, HOSHENG (1)
7,344,528 Optic fiber probe 9 2005
 
UNIVERSITY OF CINCINNATI (1)
7,300,414 Transcranial ultrasound thrombolysis system and method of treating a stroke 3 2000
 
Other [Check patent profile for assignment information] (2)
6,949,094 Miniature refrigeration system for cryothermal ablation catheter 2 2002
7,615,048 Engine with liquid piston 0 2005