US Patent No: 5,944,687

Number of patents in Portfolio can not be more than 2000

Opto-acoustic transducer for medical applications

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Abstract

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This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
LAWRENCE LIVERMORE NATIONAL SECURITY, LLCLIVERMORE, CA1037

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benett, William Livermore, CA 7 289
Celliers, Peter Berkeley, CA 6 234
Da, Silva Luiz Danville, CA 12 595
Glinsky, Michael Livermore, CA 8 348
Krulevich, Peter Pleasanton, CA 2 85
Lee, Abraham Walnut Creek, CA 9 92
London, Richard Orinda, CA 8 336
Maitland, Duncan Livermore, CA 5 206
Matthews, Dennis Moss Beach, CA 10 569

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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Other [Check patent profile for assignment information] (11)
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The United States of America as represented by the Secretary of the Army (1)
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The Beth Israel Hospital Association (1)
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YALE UNIVERSITY (1)
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WHITE STAR HOLDINGS LTD. (1)
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
6,949,094 Miniature refrigeration system for cryothermal ablation catheter 4 2002
* 2003/0130,650 Miniature refrigeration system for cryothermal ablation catheter 2 2002
* 2004/0082,844 Optical-acoustic imaging device 13 2003
7,615,048 Engine with liquid piston 0 2005
* 2015/0045,645 OPTICAL IMAGING PROBE 2 2014
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (3)
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TU, HOSHENG (1)
* 7,344,528 Optic fiber probe 17 2005
 
Teiji Nakayama (1)
* 2009/0270,846 CATHETER, EXAMINATION SYSTEM AND THROMBUS REMOVING DEVICE 0 2006
 
AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTE. LTD. (2)
7,359,523 Fluidic acoustic transducer 1 2003
* 2004/0258,258 Fluidic acoustic transducer 0 2003
 
PALOMAR MEDICAL TECHNOLOGIES, LLC (10)
8,346,347 Skin optical characterization device 3 2006
* 2007/0060,819 Skin optical characterization device 19 2006
7,942,915 Phototreatment device for use with coolants 6 2006
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8,002,768 Light energy delivery head 5 2010
8,109,924 Heads for dermatology treatment 3 2011
8,328,796 Light energy delivery head 2 2011
 
Vascular Imaging Corporation (23)
7,245,789 Systems and methods for minimally-invasive optical-acoustic imaging 44 2002
* 2004/0067,000 Systems and methods for minimally-invasive optical-acoustic imaging 15 2002
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* 7,599,588 Optical imaging probe connector 12 2005
* 2007/0116,408 Optical imaging probe connector 15 2005
7,447,388 Systems and methods for minimally-invasive optical-acoustic imaging 21 2007
8,926,519 Opitcal-acoustic imaging device 4 2008
7,660,492 Systems and methods for minimally-invasive optical-acoustic imaging 15 2008
* 2009/0059,727 SYSTEMS AND METHODS FOR MINIMALLY-INVASIVE OPTICAL-ACOUSTIC IMAGING 12 2008
8,560,048 Optical ultrasound receiver 5 2009
* 2010/0087,732 OPTICAL ULTRASOUND RECEIVER 11 2009
* 7,881,573 Optical imaging probe connector 10 2009
8,059,923 Systems and methods for minimally-invasive optical-acoustic imaging 12 2010
* 8,320,723 Optical imaging probe connector 6 2011
* 2011/0123,154 OPTICAL IMAGING PROBE CONNECTOR 9 2011
8,391,652 Systems and methods for minimally-invasive optical-acoustic imaging 9 2011
* 8,861,908 Optical imaging probe 3 2012
* 2013/0148,933 OPTICAL IMAGING PROBE 6 2012
8,731,340 Systems and methods for minimally-invasive optical-acoustic imaging 6 2013
9,078,561 Optical ultrasound receiver 0 2013
9,192,307 Systems and methods for minimally-invasive optical-acoustic imaging 0 2014
9,149,191 Systems and methods for minimally-invasive optical-acoustic imaging 0 2014
* 9,198,581 Optical imaging probe 0 2014
 
CANDELA CORPORATION (1)
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CYBERSONICS, INC. (9)
7,494,468 Ultrasonic medical device operating in a transverse mode 93 2003
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Cardiocavitational Systems, Inc. (1)
6,755,821 System and method for stimulation and/or enhancement of myocardial angiogenesis 27 1999
 
RIVERSIDE RESEARCH INSTITUTE (1)
* 2008/0228,073 SYSTEM AND METHOD FOR OPTOACOUSTIC IMAGING OF PERIPHERAL TISSUES 3 2008
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (5)
* 6,309,352 Real time optoacoustic monitoring of changes in tissue properties 42 1998
6,405,069 Time-resolved optoacoustic method and system for noninvasive monitoring of glucose 30 1999
7,430,445 Noninvasive blood analysis by optical probing of the veins under the tongue 7 2004
* 2008/0255,433 OPTOACOUSTIC MONITORING OF MULTIPLE PARAMETERS 16 2008
8,352,005 Noninvasive blood analysis by optical probing of the veins under the tongue 0 2008
 
BIOSENSE WEBSTER, INC. (1)
* 2008/0154,257 Real-time optoacoustic monitoring with electophysiologic catheters 5 2006
 
UNIVERSITY OF CINCINNATI (1)
* 7,300,414 Transcranial ultrasound thrombolysis system and method of treating a stroke 8 2000
 
SELVA MEDICAL, INC. (4)
6,368,318 Opto-acoustic recanilization delivery system 4 1998
6,210,400 Flexible flow apparatus and method for the disruption of occlusions 30 1998
6,440,124 Flexible flow apparatus and method for the disruption of occlusions 4 2000
* 2005/0021,013 Photoacoustic removal of occlusions from blood vessels 28 2002
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (2)
* 6,379,325 Opto-acoustic transducer for medical applications 31 1999
* 2002/0045,890 Opto-acoustic thrombolysis 48 2001
 
Bio scan Ltd (1)
* 2005/0131,289 Ultrasonic transducer probe 23 2005
 
DEPUY ACROMED, INC. (2)
* 7,081,113 Helical probe 5 2003
* 2004/0267,251 Helical probe 9 2003
 
Endo Vasix, Inc. (2)
6,547,779 Flexible flow apparatus and method for the disruption of occlusions 63 1999
6,527,763 Flow apparatus for the disruption of occlusions 29 2001
 
BioScan Ltd (1)
* 2007/0123,776 Ultrasonic probing device with distributed sensing elements 3 2004
 
PALOMAR MEDICAL TECHNOLOGIES, INC. (1)
8,182,473 Cooling system for a photocosmetic device 12 2006
 
ALLERGAN SALES, INC. (1)
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Cynosure, Inc. (1)
9,028,536 Picosecond laser apparatus and methods for its operation and use 0 2009
 
THE GEORGE WASHINGTON UNIVERSITY (2)
* 7,999,945 Optical coherence tomography / acoustic radiation force imaging probe 5 2008
8,184,351 Amplified bimorph scanning mirror, optical system and method of scanning 0 2009
* Cited By Examiner