Influenza vaccine
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United States of America Patent
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Sep 7, 1999
Grant Date -
N/A
app pub date -
Apr 6, 1998
filing date -
Apr 9, 1997
priority date (Note) -
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Abstract
The present invention is concerned with an Influenza surface antigen vaccine obtainable by production from Influenza Viruses propagated on animal cell culture and having a host cell DNA content equal to or less than 25 pg per dose. The present invention is also concerned with a method for the preparation of surface antigen proteins from Influenza Viruses propagated on an animal cell culture comprising the subsequent steps of: a. treatment of the whole virus containing fluid obtained from the cell culture with a DNA digesting enzyme, and b. adding a cationic detergent, followed by isolation of the surface antigen proteins.
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