Oral dosage-forms containing a .beta.-lactam antibiotic
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United States of America Patent
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Sep 7, 1999
Grant Date -
N/A
app pub date -
Aug 6, 1997
filing date -
Feb 8, 1995
priority date (Note) -
In Force
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Abstract
A granulate, containing at least 50 wt. % of a water soluble .beta.-lactam antibiotic, is provided. A process to prepare a granulate containing such .beta.-lactam antibiotic comprises moistening components making up the granulate with an aqueous solution containing no substantial amount of a wet granulation binding agent. Oral dosage-forms, which contain the said antibiotic in a granular form, a cellulose product and a disintegrant and which quickly disperse when placed in an aqueous environment, are disclosed, as well as a method for the preparation of the dosage-forms.
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