Method and article to induce hematopoietic expansion
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United States of America Patent
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Sep 7, 1999
Issued Date -
N/A
app pub date -
Apr 30, 1998
filing date -
May 3, 1997
priority date (Note) -
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Abstract
An article and method to create retrievable sites of implantable and transplantable bone marrow, in a human or animal recipient, by implanting bone-marrow inducing conjugates of collagen and demineralized freeze-dried bone allograft (DFDBA) into accessible soft or hard tissue sites is provided. The implantation of such collagen-DFDBA conjugate grafts into suitable ectotrophic sites results in the formation of bone-marrow and hematopoietic tissue within the implant. By removing all or a portion of the bone marrow containing areas of the implant, an additional source of hematopoietic tissue and bone marrow cells is formed which can subsequently be transplanted into the same individual as an autograft, or a related or compatible individual as an allograft.
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