US Patent No: 5,948,428

Number of patents in Portfolio can not be more than 2000

Compositions and therapeutic methods using morphogenic proteins and stimulatory factors

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

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First Claim

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all claims..

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MARIEL THERAPEUTICS, INC.NEW YORK, NY85

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, John C San Antonio, TX 58 1246
Yeh, Lee-Chuan C San Antonio, TX 17 643

Cited Art Landscape

Patent Info (Count) # Cites Year
 
STRYKER CORPORATION (7)
* 5,011,691 Osteogenic devices 187 1989
* 5,171,574 Bone collagen matrix for implants 99 1990
* 5,108,753 Osteogenic devices 125 1990
* 5,162,114 Bone collagen matrix for xenogenic implants 80 1990
* 5,344,654 Prosthetic devices having enhanced osteogenic properties 103 1992
* 5,324,819 Osteogenic proteins 92 1992
* 5,354,557 Osteogenic devices 98 1992
 
Bioscience Consultants (1)
* 5,531,791 Composition for repair of defects in osseous tissues, method of making, and prosthesis 121 1993
 
GENETICS INSTITUTE, LLC (1)
* 5,459,047 BMP-6 proteins 47 1994
 
MARIEL THERAPEUTICS, INC. (1)
* 5,258,494 Osteogenic proteins 49 1992
 
WARSAW ORTHOPEDIC, INC. (1)
* 5,484,601 Flowable demineralized bone powder composition and its use in bone repair 61 1991
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (1)
* 5,461,034 Osteogenic growth polypeptides identified from regenerating bone marrow 29 1993
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (63)
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7,258,891 Stent mounting assembly and a method of using the same to coat a stent 20 2003
7,186,789 Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings 14 2003
7,285,304 Fluid treatment of a polymeric coating on an implantable medical device 23 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 63 2003
7,563,324 System and method for coating an implantable medical device 38 2003
7,699,890 Medicated porous metal prosthesis and a method of making the same 2 2004
7,553,377 Apparatus and method for electrostatic coating of an abluminal stent surface 15 2004
7,329,366 Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 9 2004
7,077,860 Method of reducing or eliminating thrombus formation 27 2004
8,568,469 Stent locking element and a method of securing a stent on a delivery system 0 2004
8,172,897 Polymer and metal composite implantable medical devices 0 2004
7,297,159 Selective coating of medical devices 9 2004
7,229,471 Compositions containing fast-leaching plasticizers for improved performance of medical devices 76 2004
8,778,256 Deformation of a polymer tube in the fabrication of a medical article 0 2004
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7,381,048 Stents with profiles for gripping a balloon catheter and molds for fabricating stents 2 2005
7,291,166 Polymeric stent patterns 20 2005
7,875,283 Biodegradable polymers for use with implantable medical devices 7 2005
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7,989,018 Fluid treatment of a polymeric coating on an implantable medical device 2 2006
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7,761,968 Method of crimping a polymeric stent 11 2006
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8,197,879 Method for selectively coating surfaces of a stent 0 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 1 2007
7,662,326 Compositions containing fast-leaching plasticizers for improved performance of medical devices 1 2007
7,955,381 Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 1 2007
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ABBOTT CARDIOVASCULAR SYSTEMS INC. (28)
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8,017,237 Nanoshells on polymers 3 2006
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8,343,530 Polymer-and polymer blend-bioceramic composite implantable medical devices 0 2006
8,486,135 Implantable medical devices fabricated from branched polymers 0 2007
8,262,723 Implantable medical devices fabricated from polymer blends with star-block copolymers 0 2007
8,034,287 Radiation sterilization of medical devices 12 2007
7,951,194 Bioabsorbable stent with radiopaque coating 2 2007
7,829,008 Fabricating a stent from a blow molded tube 5 2007
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8,535,372 Bioabsorbable stent with prohealing layer 0 2007
8,128,688 Carbon coating on an implantable device 0 2007
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NOVOZYMES BIOPHARMA DK A/S (15)
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7,094,577 Insulin and albumin fusion protein 8 2002
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7,056,701 Hormone and albumin fusion protein 12 2002
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7,250,550 Synthetic bone substitute material 22 2004
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WARSAW ORTHOPEDIC, INC. (6)
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W.R. GRACE & CO.-CONN. (5)
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LIFENET HEALTH (4)
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Other [Check patent profile for assignment information] (1)
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