Compositions and therapeutic methods using morphogenic proteins and stimulatory factors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO

5948428

SERIAL NO

08761468

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MARIEL THERAPEUTICS, INC.NEW YORK, NY84

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, John C San Antonio, TX 52 1520
Yeh, Lee-Chuan C San Antonio, TX 17 730

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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