US Patent No: 5,948,428

Number of patents in Portfolio can not be more than 2000

Compositions and therapeutic methods using morphogenic proteins and stimulatory factors

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Abstract

The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
STRYKER CORPORATIONKALAMAZOO, MI896

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, John C San Antonio, TX 52 1027
Yeh, Lee-Chuan C San Antonio, TX 17 514

Cited Art

Patent Info (Count) # Cites Year
 
STRYKER CORPORATION (8)
5,011,691 Osteogenic devices 169 1989
5,171,574 Bone collagen matrix for implants 80 1990
5,108,753 Osteogenic devices 117 1990
5,162,114 Bone collagen matrix for xenogenic implants 65 1990
5,344,654 Prosthetic devices having enhanced osteogenic properties 90 1992
5,324,819 Osteogenic proteins 87 1992
5,354,557 Osteogenic devices 86 1992
5,258,494 Osteogenic proteins 47 1992
 
BIOSCIENCE CONSULTANTS (1)
5,531,791 Composition for repair of defects in osseous tissues, method of making, and prosthesis 86 1993
 
GENETICS INSTITUTE, LLC (1)
5,459,047 BMP-6 proteins 45 1994
 
WARSAW ORTHOPEDIC, INC. (1)
5,484,601 Flowable demineralized bone powder composition and its use in bone repair 44 1991
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (1)
5,461,034 Osteogenic growth polypeptides identified from regenerating bone marrow 29 1993

Patent Citation Ranking

Forward Cites

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Other [Check patent profile for assignment information] (1)
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