Pharmaceutical formulations having improved disintegration and/or absorptivity
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United States of America Patent
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-
Sep 7, 1999
Issued Date -
N/A
app pub date -
Jun 4, 1997
filing date -
Jan 9, 1995
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An oral solid dosage form, comprising a compressed tablet including an excipient comprising (a) microcrystalline cellulose; and (b) a compressibility augmenting agent which (I) physically restricts the proximity of the interface between adjacent cellulose surfaces (e.g., silicon dioxide); or (ii) inhibits interactions between adjacent cellulose surfaces (e.g., sodium lauryl sulfate); or (iii) accomplishes both (i) and (ii) above; together with an active agent, is disclosed which provides improved disintegration and/or absorptivity to the oral solid dosage form when orally administered to human patients. The excipient comprises agglomerated particles of said microcrystalline cellulose and said compressibility augmenting agent in intimate association with each other.
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